heart & blood vessels

CSK

Do Genes Influence Your Blood Pressure? (CSK)

Written by Aleksa Ristic, MS (Pharmacy) on January 22nd, 2021

The CSK gene inhibits angiotensin II, a major blood-pressure-increasing protein. Read this post to check your variants and get tailored tips!

Summary

The CSK gene suppresses the production of angiotensin II, a major blood-pressure-increasing protein.

Specific gene variants have been associated with relatively higher blood pressure. They likely reduce CSK activity and increase angiotensin II levels.

Read this post to learn about natural ways to control blood pressure by targeting the CSK gene.

The CSK Gene & Blood Pressure

The CSK gene helps make a protein that suppresses angiotensin II production. Angiotensin II is the key component of the renin-angiotensin system (RAS). It raises blood pressure by shrinking the blood vessels, increasing blood volume, and activating the sympathetic nervous system [R, R, R].

Popular blood pressure drugs, ACE inhibitors, target the RAS system by inhibiting the enzyme that produces angiotensin II [R].

Did you know? The CSK gene belongs to a group of 21 genes associated with blood pressure. Using cutting-edge genetic methods, scientists concluded that, of all those genes, CSK is most likely the one directly influencing blood pressure [R]!

Your CSK Results for Blood Pressure

SNP Table

variant	genotype	frequency	risk allele
rs6495122
rs1378942

Primary SNPs:

rs6495122 [R]:

‘C’ – associated with relatively lower blood pressure
‘A’ – associated with relatively higher blood pressure
The ‘A’ allele may increase angiotensin II levels by reducing CSK activity.

rs1378942 [R]:

‘A’ – associated with relatively lower blood pressure
‘C’ – associated with relatively higher blood pressure
The ‘C’ allele may increase angiotensin II levels by reducing CSK activity.

Recommendations

Garlic

Garlic may act as a natural ACE inhibitor and reduce angiotensin II levels [R, R].

Several meta-analyses found that supplementation with a garlic extract (600-2,400 mg/day) may lower systolic (by 7-16 mmHg) and diastolic (by 5-9 mmHg) blood pressure. Garlic may be effective only in people with high blood pressure [R, R, R, R, R, R].

Garlic may reduce blood pressure by targeting your CSK variants.

Hibiscus

Hibiscus (Hibiscus sabdariffa) tea may lower systolic (by 4.71-7.58 mmHg) and diastolic (by 3.53-4.08 mmHg) blood pressure, according to two meta-analyses and four trials of people with high blood pressure [R, R, R, R, R, R].

A dose adjusted to each person’s weight (0.15 g/kg/day) was as effective as drug treatment in two studies. Similarly, hibiscus tea (10 g/day) was as effective as an ACE inhibitor (lisinopril) in one trial [R, R, R].

Hibiscus may lower blood pressure in part by acting as a natural ACE inhibitor and reducing angiotensin II levels [R].

Consider drinking hibiscus tea to lessen the impact of your CSK gene on blood pressure.

Casein Peptides

Casein is the primary protein from dairy products. Research has identified several peptides inside casein that can inhibit ACE [R, R].

Supplementation with casein tripeptides may lower systolic (by 1.28-5.63 mmHg) and diastolic (by 0.59-1.51 mmHg) blood pressure, according to three meta-analyses. Casein peptides were most effective in Japanese populations [R, R, R].

Casein peptides may reduce blood pressure by targeting your gene variants.

Aleksa Ristic

MS (Pharmacy)

Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.

Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions—writing and health—and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.

Disclaimer

The information on this website has not been evaluated by the Food & Drug Administration or any other official medical body. This information is presented for educational purposes only, and may not be used to diagnose or treat any illness or disease.

Also keep in mind that the “Risk Score” presented in this post is based only on a select number of SNPs, and therefore only represents a small portion of your total risk as an individual. Furthermore, these analyses are based primarily on associational studies, which do not necessarily imply causation. Finally, many other (non-genetic) factors can also play a significant role in the development of a disease or health condition — therefore, carrying any of the risk-associated genotypes discussed in this post does not necessarily mean you are at increased risk of developing a major health condition.

Always consult your doctor before acting on any information or recommendations discussed in this post — especially if you are pregnant, nursing, taking medication, or have been officially diagnosed with a medical condition.

More heart & blood vessels blogs

The Gene That Protects Your Heart (PON1) The Link Between Methylation, Cholesterol, and Heart Disease (PEMT) Are You Genetically Vulnerable to Heart Disease (NOS3)? Caffeine: Your Friend or Foe? (CYP1A2) Is This Cholesterol Gene Linked To Lifespan? (CETP) Does This Cholesterol-Related Gene Affect Lifespan? (APOC1) The Complex Relationship Between CRP and Longevity Does This Gene Affect Salt Sensitivity and Blood Pressure? (SLC4A5) How Does This Fat Transport Gene Affect Metabolic & Cardiovascular Disease? (APOA5) Can This Gene Influence Your Risk of Heart Disease (COMT)?

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Summary The CSK Gene & Blood Pressure Your CSK Results for Blood Pressure

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