G= better response to inhaled corticosteroids in patients with asthma [R].
In Asian (Japanese) populations, the presence of an (G) allele represents a 1.3 fold increased risk of autoimmune thyroid disease, and for those with autoimmune thyroid disease, a 1.5 fold increased risk of type-1 diabetes R.
Implicated as a (minor) risk factor for developing rheumatoid arthritis (RA). A study of 2,000+ European RA patients led to a calculated odds ratio of 1.13 (CI: 1.03 - 1.24) for the (G) risk allele. [R]
In a study of 395 Spanish patients with lupus, (G) allele carriers were calculated to have an odds ratio of 1.71 (CI: 1.18-2.49, p=0.003, p(corr) = 0.006).[R]
In a different study involving recipients of liver transplants, the (G) allele was significantly associated with acute rejection (odds ratio 1.49, p(corr)=0.038). Patients who lacked this allele had the lowest risk of acute rejection development. Allograft survival data did not show statistical differences between genotypes.[R] [R]
Significantly associated with type 1 diabetes odds ratio 1.37 and 1.28 [R].