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CD28
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs767763807 | |||
| rs3116488 | |||
| rs55950710 | |||
| rs5837875 | |||
| rs1267158897 | |||
| rs1451736305 | |||
| rs190179477 | |||
| rs3116496 | |||
| rs3116497 | |||
| rs72932400 | |||
| rs995151852 | |||
| rs13390252 | |||
| rs17449270 | |||
| rs17533699 | |||
| rs17533727 | |||
| rs45620941 | |||
| rs55634483 | |||
| rs10169758 | |||
| rs10187250 | |||
| rs10211209 |
Find on This Page
Summary
CD28 encodes a receptor that stimulates the growth and activation of T cells. Variants of CD28 may play a role in rheumatoid arthritis by promoting the production of autoantibodies.
Lifestyle, diet, and supplement modifications may counteract the effects of these variants by increasing the number of certain types of T cells that express CD28.
Protein names
Found in These Blog Articles
More Information
The CD28 gene encodes a receptor that stimulates the development and activation of certain types of T cells [R, R].
CD28 is typically activated along with other stimulatory receptors, such as CD40 and TCR. The combined signals of CD28 and other receptors leads to the production of inflammatory cytokines as part of an immune response [R, R].
Variants in the CD28 gene may make the immune system more likely to produce rheumatoid factor, a type of antibody that can attack and destroy the body’s own joint and connective tissues [R].
People who are early in the progression of rheumatoid arthritis tend to produce a higher than normal number of white blood cells that express CD3 and CD8, but not CD28. Rheumatoid arthritis patients also often produce white blood cells that express CD4, but not CD28. CD28 in these combinations may help prevent the production of harmful rheumatoid factor [R, R].
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