rs20541 is a G/A polymorphism in the IL13 gene and is associated with IgE levels. 

The AA genotype was significantly related to an increased risk of eczema (OR=2.38) [R]. 

The ''A'' allele was associated with increased odds of allergic rhinitis (AR) in mixed age groups [R]. 

Compared with the GG genotype, the AA genotype, was significantly positively related to the risk of rhinoconjunctivitis: the adjusted odds ratio was 1.65 [R].

The ''A'' allele was significantly associated with asthma [R].

''A'' allele had a reduced risk of colorectal cancer (CRC) (P(trend) = 0.02) [R].

The ''A'' allele was significantly associated with increased eosinophil count (P < .011) and increased serum total IgE (P < .054) [R]. 

The ''G'' allele was susceptible to psoriasis, while the A allele was protective [R].

''A'' allele was significantly associated with protection from psoriatic arthritis (PsA) [R]. 

''A'' allele showed association with development of non-atopic hand eczema  (OR = 3.38) [R]. 

''A'' allele was most strongly associated with susceptibility to Chronic obstructive pulmonary disease (COPD) [R].

The minor allele ''A'' is the risk allele for asthma but the protective allele for psoriasis [R]. 

GA/AA genotypes were significantly associated with reduced risk for glioma (OR = 0.85, GA/AA vs. GG) [R]. 

The GA genotype was significantly related to a decreased risk of hepatocellular carcinoma (HCC)  (OR = 0.54, 95%) [R].

''G'' allele increased the risk of disease progression to late-stage schistosomiasis (OR = 1.46, p = 0.035), whereas ''A'' allele showed a protective role against development of late-stage schistosomiasis (OR = 0.61, p = 0.002) [R].

 

rs20541

Parent Gene: IL13

Importance: 5
Less common allele: A = 27%
More common allele: G = 73%
My Genotype: Log In
Risk Allele: G, A, A, G, A, G

Disease/Trait: Psoriasis

The G allele of rs20541 is reported to be associated with Psoriasis (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Psoriasis.

Disease/Trait: Serum Ige Measurement

The A allele of rs20541 is reported to be associated with Serum Ige Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with IgE levels.

Disease/Trait: Hodgkins Lymphoma

rs20541 is associated with Hodgkins Lymphoma (R) . It is reported to increased association with Hodgkin's lymphoma (EBV-negative cHL). No specific risk allele was identified in the study.

Disease/Trait: Allergy

The A allele of rs20541 is reported to be associated with Allergy (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Self-reported allergy.

Disease/Trait: Psoriasis

The G allele of rs20541 is reported to be associated with Psoriasis (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Psoriasis.

Disease/Trait: Psoriasis

The A allele of rs20541 is reported to be associated with Psoriasis (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Psoriasis.

Disease/Trait: Cutaneous Psoriasis Measurement

The G allele of rs20541 is reported to be associated with Cutaneous Psoriasis Measurement . Your genotype was not identified for this SNP so we are unable to comment on your association with Cutaneous psoriasis.

Disease/Trait: Psoriasis

The G allele of rs20541 is reported to be associated with Psoriasis (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cutaneous psoriasis.