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IL4
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs10066660 | |||
| rs10066662 | |||
| rs11479198 | |||
| rs2070874 | |||
| rs2227284 | |||
| rs2243268 | |||
| rs2243269 | |||
| rs2243282 | |||
| rs2243289 | |||
| rs2243290 | |||
| rs734244 | |||
| rs11242122 | |||
| rs4426908 | |||
| rs56279116 | |||
| rs781148776 | |||
| rs2243266 | |||
| rs2243267 | |||
| rs2243270 | |||
| rs2243274 | |||
| rs2243284 |
Find on This Page
Summary
The IL4 gene encodes interleukin-4, an important inflammatory marker [R].
IL-4 is a proinflammatory cytokine. It stimulates the Th2 immune response, meaning that it promotes an antibody response to pathogens. High IL-4 levels may contribute to allergic reactions [R, R, R].
IL-4 also plays a role in DNA synthesis [R].
Variants in IL4 have been linked to [R, R, R]:
- Asthma
- Post-traumatic disorders
- Systemic lupus erythematosus
Protein names
Found in These Blog Articles
GHR Function
Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages.
More Information
From UniProt: Ischemic stroke (ISCHSTR): A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. [MIM:601367]
From NCBI Gene: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] From UniProt: Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages.
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