Mechanism:

  • Less production of DHA .  Lowered ability to elongate and desaturate fatty acids (GG). [R]
  • Slightly less lowered ability to elongate and desaturate fatty acids (G). [R]
  • Normal ability to elongate and desaturate fatty acids (A). [R]

GG (minor):

  • 56% less EPA with a given level of ALA [R]
  • Decrease of Docosahexaenoic acid (DHA) [R]. DHA is a type of omega-3, which is the primary component of a brain cell. The decreased ability transform fatty acids into Docosahexaenoic acid (DHA) results in a lower IQ for non-breast fed children. Breast milk contains usable DHA .
  • Breastfed children had an average IQ in low the 100s. [R] Non-breastfed children had IQs in the upper 90s.
  • Low levels of High-density Lipoprotein Cholesterol (HDL-C) [R]
  • Moderately increases the risk for Type-2 Diabetes.
  • Intensive lifestyle intervention (ILI) treatment shows a significantly positive HDL-C response.

AG:

  • 26% less EPA with a given level of ALA [R]
  • Low levels of High-density Lipoprotein Cholesterol (HDL-C) [R]
  • Breastfed children had an average IQ in low the 100s. [R] Non-breastfed children had IQs in the upper 90s.
  • Moderately increases the risk for Type-2 Diabetes.
  • Intensive lifestyle intervention (ILI) treatment shows a significantly positive HDL-C response.

AA (Major):

  • Normal conversion of ALA to EPA . Normal ability to produce DHA, which results in the smallest decrease in average IQ in formula-fed children [R].
  • Breastfed children have the highest IQ in some studies [R].
  • Normal High-density Lipoprotein Cholesterol [R].

rs1535

Parent Gene: FADS1, FADS2

Importance: 5
Less common allele: G = 32%
More common allele: A = 68%
My Genotype: Log In
Risk Allele: G, G, A, A, A, A, A, A, A

Disease/Trait: High Density Lipoprotein Cholesterol Measurement

The G allele of rs1535 is reported to be associated with High Density Lipoprotein Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Metabolic syndrome (HDL).

Disease/Trait: Metabolic Syndrome

The G allele of rs1535 is reported to be associated with Metabolic Syndrome (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Metabolic syndrome (HDL).

Disease/Trait: Response To Statin

The G allele of rs1535 is reported to be associated with Response To Statin (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Response to statin therapy (HDL, sum).

Disease/Trait: Inflammatory Bowel Disease

rs1535 is associated with Inflammatory Bowel Disease (R) . It is reported to association with Inflammatory bowel disease (EA). No specific risk allele was identified in the study.

Disease/Trait: Blood Metabolite Measurement

The A allele of rs1535 is reported to be associated with Blood Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine diacyl C34:3).

Disease/Trait: Glycerophospholipid Measurement

The A allele of rs1535 is reported to be associated with Glycerophospholipid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine diacyl C34:3).

Disease/Trait: Blood Metabolite Measurement

The A allele of rs1535 is reported to be associated with Blood Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine acyl-alkyl C36:3).

Disease/Trait: Glycerophospholipid Measurement

The A allele of rs1535 is reported to be associated with Glycerophospholipid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine acyl-alkyl C36:3).

Disease/Trait: Trans Fatty Acid Measurement

The A allele of rs1535 is reported to be associated with Trans Fatty Acid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Trans fatty acid levels (Cis/trans-18:2, EA).

Disease/Trait: Cis/Trans-18:2 Fatty Acid Measurement

The A allele of rs1535 is reported to be associated with Cis/trans-18:2 Fatty Acid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Trans fatty acid levels (Cis/trans-18:2, EA).

Disease/Trait: Alpha-Linolenic Acid Measurement

The A allele of rs1535 is reported to be associated with Alpha-linolenic Acid Measurement . Your genotype was not identified for this SNP so we are unable to comment on your association with Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid).

Disease/Trait: Low Density Lipoprotein Cholesterol Measurement

The A allele of rs1535 is reported to be associated with Low Density Lipoprotein Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with LDL cholesterol levels (Trans-ethnic initial).

Disease/Trait: Total Cholesterol Measurement

The A allele of rs1535 is reported to be associated with Total Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Total cholesterol levels (Trans-ethnic initial).