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FADS2
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs174573 | |||
| rs174574 | |||
| rs61897793 | |||
| rs174568 | |||
| rs1535 | |||
| rs174562 | |||
| rs199573356 | |||
| rs1186937520 | |||
| rs174566 | |||
| rs174567 | |||
| rs174572 | |||
| rs174575 | |||
| rs174576 | |||
| rs174577 | |||
| rs174578 | |||
| rs174579 | |||
| rs174580 | |||
| rs174581 | |||
| rs174582 | |||
| rs192793035 |
Summary
FADS2 helps with the conversion of fatty acids to DHA and DPA (R), which is critical for cognitive function (R).
It was reported the FADS2 interacts with breastfeeding such that breastfed children with the "C" version of the gene appear about 7 intelligence quotient (IQ) points higher than those with the less common "G" version (less than this when adjusted for maternal IQ) (R).
An attempt to replicate this study in 5934 8 year old children failed: No relationship of the common C allele to negative effects of formula feeding was apparent, and contra to the original report, the rare GG homozygote children performed worse when formula fed than other children on formula milk.
A study of over 700 families recently found no evidence for either main or moderating effects of the original SNP (rs174575), nor of two additional FADS2 polymorphisms (rs1535 and rs174583), nor any effect of maternal FADS2 status on offspring IQ (R).
Protein names
Found in These Blog Articles
More Information
FADS2
-
Fatty Acid Desaturase (FADS) [R]
-
These enzymes regulate the process of unsaturation of fatty acids [R]
-
Some SNPS result in a lower than average High density Lipoprotein Cholesterol (HDL-C) level which increases the risk for Type-2 Diabetes.[R]
-
Lowered ability to elongate and desaturate fatty acids prevents these acids from being used during brain cell development. [R]
-
This leads to a lower IQ. (approximately 6-8 points in loss)
-
-
Some SNPS lead to an increased ability to elongate and desaturate fatty acids. [R]
-
However, there is no study on the effect this has on a child's IQ.
-
Some SNPS can increase risk of developing Coronary Artery Disease (CAD) [R]
Advanced Information:
-
Regulation of the unsaturation of fatty acids is caused by the addition of double bonds between defined carbons of the fatty acyl chain. [R]
-
These acids include but not limited to
-
α-Linolenic Acid (ALA).
-
Docosahexaenoic acid (DHA).
-
Linoleic Acid.
-
Eicosadienoic Acid.
-
Dihomo-gamma-linolenic Acid (DGLA)
-
Arachidonic Acid (AA).
-
Adrenic Acid.
-
Docosapentaenoic Acid (Osbond Acid).
-
Eicosapentaenoic Acid (EPA).
-
-
Lifestyle & Supplement Interactions
Potential Fixes:
-
Improved lifestyle choices have been shown to have a significant improvement in increasing High density Lipoprotein Cholesterol (HDL-C). These lifestyle choices including diet and exercise. [R]
-
Breastfeeding or giving a child DHA prevents the need to elongate and desaturate key fatty acids which prevented any loss in IQ development form a shortage of key fatty acids that are required for brain development. [R]
-
Improved diet and lifestyle choices which including diet and exercise significantly decrease the moderate risk this SNP causes. [R]
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