A high incidence of the ''T'' allele is seen in male ulcerative colitis (UC) patients (OR=2.585, p=0.023) and inflammatory bowel disease (IBD) (OR=2.039, p=0.042) patients, and in female Crohn's disease (CD) patients (OR=2.329, ρ value=0.039) [R]. 

Time to progression was significantly improved in presence of the ''C'' allele in patients with gastrointestinal stromal tumours treated with imatinib therapy [R]. 

''T'' allele had a positive association with ulcerative colitis (UC) in patients with Caucasian origin (P = 0.005, OR = 2.015) [R].

''C'' allele was significantly associated with major molecular response in newly diagnosed chronic myeloid leukemia patients receiving imatinib therapy [R]. 


Parent Gene: MIR4750, SLC22A4, SLC22A5

Importance: 2
Less common allele: T = 13%
More common allele: C = 87%
My Genotype: Log In