Summary of TERT
The TERT gene encodes one component of an enzyme called telomerase. Telomerase maintains telomeres and counteracts the shortening of telomeres to stop cells from dividing or self destructing. Telomerase is also abnormally active in most cancer cells (R).
The Function of TERT
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
Recommended name:Telomerase reverse transcriptase
Telomerase catalytic subunit
Telomerase-associated protein 2
- RS10069690 (TERT) ??
- RS13167280 (TERT) ??
- RS2075786 (TERT) ??
- RS2242652 (TERT) ??
- RS2735940 (TERT) ??
- RS2736098 (TERT) ??
- RS2736100 (TERT) ??
- RS2736122 (TERT) ??
- RS2853669 (TERT) ??
- RS2853672 (TERT) ??
- RS2853676 (TERT) ??
- RS2853677 (TERT) ??
- RS31490 (TERT) ??
- RS34094720 (TERT) ??
- RS380286 (TERT) ??
- RS401681 (TERT) ??
- RS4635969 (TERT) ??
- RS4975605 (TERT) ??
- RS7705526 (TERT) ??
- RS7725218 (TERT) ??
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Top Gene-Substance Interactions
TERT Interacts with These Diseases
Substances That Increase TERT
Substances That Decrease TERT
breast cancer Genetics Home Reference provides information about breast cancer . cholangiocarcinoma Genetics Home Reference provides information about cholangiocarcinoma. dyskeratosis congenita At least 18 mutations in the TERT gene have been identified in people with dyskeratosis congenita. This disorder is characterized by changes in skin coloring (pigmentation), white patches inside the mouth (oral leukoplakia), and abnormally formed fingernails and toenails (nail dystrophy). People with dyskeratosis congenita have an increased risk of developing several life-threatening conditions, including cancer and a progressive lung disease called pulmonary fibrosis. Many affected individuals also develop a serious condition called aplastic anemia, also known as bone marrow failure, which occurs when the bone marrow does not produce enough new blood cells. Most of the TERT gene mutations that cause dyskeratosis congenita change single protein building blocks (amino acids) in the hTERT protein, causing it to be unstable or dysfunctional. The mutations interfere with telomerase function, leading to impaired maintenance of telomeres and reduced telomere length. Cells that divide rapidly are especially vulnerable to the effects of shortened telomeres. As a result, people with dyskeratosis congenita may experience a variety of problems affecting quickly dividing cells in the body such as cells of the nail beds, hair follicles, skin, lining of the mouth (oral mucosa), and bone marrow. Breakage and instability of chromosomes resulting from inadequate telomere maintenance may lead to genetic changes that allow cells to divide in an uncontrolled way, resulting in the development of cancer in some people with dyskeratosis congenita. idiopathic pulmonary fibrosis At least 23 mutations in the TERT gene have been identified in people with the progressive lung disease idiopathic pulmonary fibrosis. Mutations in this gene have been found in cases that run in families (familial pulmonary fibrosis) and, less commonly, in isolated (sporadic) cases. Some individuals with idiopathic pulmonary fibrosis due to TERC gene mutations have family members with other features of dyskeratosis congenita (described above), such as aplastic anemia or cancer. Mutations in the TERT gene reduce or eliminate the function of telomerase, which allows telomeres to become abnormally short as cells divide. The shortened telomeres likely trigger cells that divide rapidly, such as cells that line the inside of the lungs, to stop dividing or to die prematurely. However, researchers are unsure how shortened telomeres contribute to the progressive scarring and lung damage characteristic of idiopathic pulmonary fibrosis. Idiopathic pulmonary fibrosis is a complex disease that is probably caused by a combination of genetic and environmental factors. Studies suggest that many affected people with TERT gene mutations may have also been exposed to environmental risk factors, such as cigarette smoke or certain kinds of dust or fumes. It is possible that mutations in the TERT gene increase a person's risk of developing idiopathic pulmonary fibrosis, and then exposure to certain environmental factors can trigger the disease. cancers Mutations in the TERT gene have been associated with an increased risk of various cancers, in particular a type of skin cancer called melanoma and a form of blood cancer called acute myeloid leukemia. Researchers suggest that these mutations may impair telomere maintenance and result in DNA damage. Damage to genes that help control the growth and development of cells can cause uncontrolled cell growth and lead to development of these cancers. other disorders TERT gene mutations have also been found in people with isolated aplastic anemia, a form of bone marrow failure that occurs without the other physical features of dyskeratosis congenita. Researchers suggest that mutations affecting different parts of the telomerase enzyme may account for the absence of these features. Some believe that isolated aplastic anemia caused by TERT gene mutations may actually represent a late-onset form of dyskeratosis congenita in which physical features such as nail dystrophy are mild and may not be noticeable.
The TERT gene provides instructions for making one component of an enzyme called telomerase. Telomerase maintains structures called telomeres, which are composed of repeated segments of DNA found at the ends of chromosomes. Telomeres protect chromosomes from abnormally sticking together or breaking down (degrading). In most cells, telomeres become progressively shorter as the cell divides. After a certain number of cell divisions, the telomeres become so short that they trigger the cell to stop dividing or to self-destruct (undergo apoptosis). Telomerase counteracts the shortening of telomeres by adding small repeated segments of DNA to the ends of chromosomes each time the cell divides. In most types of cells, telomerase is either undetectable or active at very low levels. However, telomerase is highly active in cells that divide rapidly, such as cells that line the lungs and gastrointestinal tract, cells in bone marrow, and cells of the developing fetus. Telomerase allows these cells to divide many times without becoming damaged or undergoing apoptosis. Telomerase is also abnormally active in most cancer cells, which grow and divide without control or order. The telomerase enzyme consists of two major components that work together. The component produced from the TERT gene is known as hTERT. The other component is produced from a gene called TERC and is known as hTR. The hTR component provides a template for creating the repeated sequence of DNA that telomerase adds to the ends of chromosomes. The hTERT component then adds the new DNA segment to chromosome ends.
Conditions with Increased Gene Activity
|Condition||Change (log2fold)||Comparison||Species||Experimental variables||Experiment name|
Conditions with Decreased Gene Activity
|Condition||Change (log2fold)||Comparison||Species||Experimental variables||Experiment name|
The following transcription factors affect gene expression:
Expressed at a high level in thymocyte subpopulations, at an intermediate level in tonsil T-lymphocytes, and at a low to undetectable level in peripheral blood T-lymphocytes.
Activated by cytotoxic events and down-regulated during aging. In peripheral T-lymphocytes, induced By CD3 and by PMA/ionomycin. Inhibited by herbimycin B.
- Trna Binding
- Transcription Coactivator Binding
- Dna Binding
- Telomerase Activity
- Telomerase Rna Reverse Transcriptase Activity
- Rna Binding
- Rna-Directed Dna Polymerase Activity
- Nucleotidyltransferase Activity
- Telomeric Dna Binding
- Protein Homodimerization Activity
- Metal Ion Binding
- Telomerase Rna Binding
- Telomere Maintenance
- Transcription, Rna-Templated
- Rna-Dependent Dna Biosynthetic Process
- Telomere Maintenance Via Telomerase
- Mitochondrion Organization
- Negative Regulation Of Gene Expression
- Dna Strand Elongation
- Positive Regulation Of Wnt Signaling Pathway
- Production Of Sirna Involved In Rna Interference
- Regulation Of Protein Stability
- Rna Biosynthetic Process
- Positive Regulation Of Hair Cycle
- Negative Regulation Of Neuron Apoptotic Process
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Glucose Import
- Response To Cadmium Ion
- Positive Regulation Of Nitric-Oxide Synthase Activity
- Negative Regulation Of Glial Cell Proliferation
- Establishment Of Protein Localization To Telomere
- Cellular Response To Hypoxia
- Dna Biosynthetic Process
- Replicative Senescence
- Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
- Positive Regulation Of Pri-Mirna Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Transdifferentiation
- Negative Regulation Of Production Of Sirna Involved In Rna Interference
- Positive Regulation Of Vascular Smooth Muscle Cell Proliferation
- Positive Regulation Of Protein Localization To Nucleolus
- Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
- Beta-Catenin-Tcf Complex Assembly
- Negative Regulation Of Endothelial Cell Apoptotic Process
- Positive Regulation Of Stem Cell Proliferation
- Negative Regulation Of Cellular Senescence
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand