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  3. AFF3

AFF3 (AF4/FMR2 family member 3)

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The Function of AFF3

Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.

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Protein names

Recommended name:

AF4/FMR2 family member 3

Alternative name(s):

Lymphoid nuclear protein related to AF4
Protein LAF-4

AFF3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10209110 (AFF3) ??
  2. RS11676922 (AFF3) ??
  3. RS4851266 (AFF3) ??
  4. RS6712515 (AFF3) ??
  5. RS7583877 (AFF3) ??
  6. RS7601137 (AFF3) ??
  7. RS9653442 (AFF3) ??

Top Gene-Substance Interactions

Substances That Increase AFF3

Substances Interaction Organism Category

Substances That Decrease AFF3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1
  • AML1a

Tissue specificity:

Preferentially expressed in lymphoid tissues, highest levels being found in the thymus.

Molecular Function:

  • Double-Stranded Dna Binding

Biological Processes:

  • Embryonic Hindlimb Morphogenesis
  • Regulation Of Transcription, Dna-Templated
  • Response To Tumor Necrosis Factor
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_03218| A730046J16| AF4/FMR2 family member 2-like protein| AF4/FMR2 family, member 3| AF4/FMR2 family member 3 isoform 2-like| AS27_15881| AS28_10473| CB1_001577024| D623_10007919| H920_13437| I79_010112| LAF4| LAF-4| lymphoid nuclear protein 4| lymphoid nuclear protein related to AF4| M91_07393| M959_08858| MDA_GLEAN10006877| MLLT2-like| MLLT2-related protein| N300_03178| N301_16519| N302_15239| N303_07495| N305_12649| N306_07846| N308_07440| N325_01734| N330_12612| N332_15003| N334_08018| N335_13611| PAL_GLEAN10003462| PANDA_008678| protein LAF-4| TREES_T100005867| UY3_15770| Y956_02774| Z169_11790| aff3

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