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rs9934438

Chromosome : 16 , Position: 31093557

Most conditions are affected by anywhere from hundreds to millions of genetic variants (SNPs). A single SNP usually has a minor contribution to a person’s overall genetic risk for a certain condition. That is why you shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to determine polygenic risk scores (PRSs), which are the basis of most health reports.

Reference Allele: G

Alternative Alleles: A, C

Associated Genes

ZNF668

HSD3B7

VKORC1

STX4

STX1B

BCKDK

PRSS53

KAT8

SETD1A

PRSS36

ITGAD

ITGAX

ARMC5

ZNF646

CCDC189

ITGAM

PRSS8

TRIM72

FUS

MAPK3

PHKG2

PYCARD

RNF40

BCL7C

COX6A2

ITGAL

PYDC1

ZNF267

FBXL19

ORAI3

PRR14

CTF1

ZNF629

TMEM265

ZNF689

ZNF843

RUSF1

SLC5A2

SRCAP

TGFB1I1

AHSP

FBRS

ZNF768

Summary

[PMID 18218987] risk of aortic calcification was calculated, adjusted for potential confounders. The T allele frequency of the VKORC1 1173C>T polymorphism was 38.8%. 1185 (37.2%) persons were homozygous CC, 1529 (48,0%) were heterozygous CT and 473 (14.8%) were homozygous TT. Persons with at least one T-allele had a statistically significant 19% (95% CI 2 to 40%) risk increase of calcification of the aortic far wall compared to CC homozygous persons[PMID 21179439] VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey

[PMID 22118051] Genetic variants in CYP (-1A2, -2C9, -2C19, -3A4 and -3A5), VKORC1 and ABCB1 genes in a black South African population: a window into diversity

[PMID 16270629] VKORC1 haplotypes and their impact on the inter-individual and inter-ethnical variability of oral anticoagulation.

[PMID 17048007] Association of warfarin dose with genes involved in its action and metabolism.

[PMID 18252229] Warfarin pharmacogenetics: CYP2C9 and VKORC1 genotypes predict different sensitivity and resistance frequencies in the Ashkenazi and Sephardi Jewish populations.

[PMID 18466099] Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans.

[PMID 18523153] Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement.

[PMID 18559094] Warfarin dose and INR related to genotypes of CYP2C9 and VKORC1 in patients with myocardial infarction.

[PMID 18596683] Dosing algorithms to predict warfarin maintenance dose in Caucasians and African Americans.

[PMID 18680736] Genetic factors contribute to patient-specific warfarin dose for Han Chinese.

[PMID 18752379] Warfarin pharmacogenetics.

[PMID 18809808] Ethnic differences in cardiovascular drug response: potential contribution of pharmacogenetics.

[PMID 18813101] Impact of VKORC1 haplotypes on long-term graft function in kidney transplantation.

[PMID 18855533] VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans.

[PMID 19074728] Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy.

[PMID 19172700] A genotyping method for VKORC1 1173C > T by Pyrosequencing technology.

[PMID 19228618] Estimation of the warfarin dose with clinical and pharmacogenetic data.

[PMID 19300499] A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.

[PMID 19955245] Warfarin sensitivity genotyping: a review of the literature and summary of patient experience.

[PMID 20585445] A novel, single algorithm approach to predict acenocoumarol dose based on CYP2C9 and VKORC1 allele variants.

[PMID 20733952] Warfarin genotyping using three different platforms.

[PMID 23124848] SNPs in VKORC1 are risk factors for systemic lupus erythematosus in asians

[PMID 23662025] Genetic variation and haplotype structure of the gene Vitamin K epoxide reductase complex, subunit 1 in the Tamilian population

[PMID 24324947] VKORC1 and CYP2C9 Genotype Variations in Relation to Warfarin Dosing in Korean Stroke Patients

[PMID 24602049] Association of gene polymorphisms with the risk of warfarin bleeding complications at therapeutic INR in patients with mechanical cardiac valves

[PMID 23691226] Novel associations of VKORC1 variants with higher acenocoumarol requirements.

[PMID 24966969] High resolution melting method to detect single nucleotide polymorphism of VKORC1 and CYP2C9

More Information

Population Alleles Frequency

ethhicity frequency	A	C
African/African-American	0.1009	–
Latino/Admixed American	0.4431	–
Ashkenazi Jewish	0.4759	–
East Asian	0.8995	–
European	0.3687	–
Other (population not assigned)	0.3699	–

Frequently Asked Questions

Why Are Alleles for This SNP Different Elsewhere? Major vs. Reference Allele Is My Variant Good or Bad? SNP vs. Mutation

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rs9934438

Associated Genes

Summary

More Information

Population Alleles Frequency

Frequently Asked Questions

Unlock Personalized Results And So Much More!

Essential Bundle

Essential

Bundle

Limited time offer 25% off

Ultimate Bundle

Policies

About

Navigation

Health reports