rs5498

In a study of the type-1 diabetes complication known as diabetic nephropathy (DN), 662 (312 female/350 male) T1D patients with DN and 620 (369/251) without DN were studied (all were Swedish Caucasians). The rs5498(G) allele was found to be significantly associated with decreased risk for diabetic nephropathy specifically in female T1D patients, with an odds ratio of 0.692 (CI: 0.5-0.958, p= 0.010).10.1186/1471-2350-9-47

A study of 552 individuals in India found an association between the rs5498(G) allele and increased risk of severe malaria, with an odds ratio 1.91 (p=0.02).[1]

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[PMID 18805939] Functional genetic polymorphisms and female reproductive disorders: part II–endometriosis.

[PMID 19048183] Interactions between rs5498 polymorphism in the ICAM1 gene and traditional risk factors influence susceptibility to coronary artery disease.

[PMID 19055786] Variations in host genes encoding adhesion molecules and susceptibility to falciparum malaria in India.

[PMID 20585554] On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women’s Genome Health Study.

[PMID 20622166] Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: a Go-DARTS study.

[PMID 23114149] [Effects of ICAM-1 Gene K469E, K56M Polymorphisms on Plasma sICAM-1 Expression Levels in Chinese Yugur, Tibetan and Han Nationalities]

[PMID 23922864] Intracellular Adhesion Molecule-1 K469E Gene Polymorphism and Risk of Diabetic Microvascular Complications: A Meta-Analysis

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[PMID 22573572] Phenotype-genotype profiles in Crohn’s disease predicted by genetic markers in autophagy-related genes (GOIA study II).

[PMID 22904330] ICAM-1 K469E polymorphism is a genetic determinant for the clinical risk factors of T2D subjects with retinopathy in Indians: a population-based case-control study.

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rs5498 is a SNP of the ICAM1 gene. It is significantly associated with ICAM-1 measurement. It is also strongly associated with diabetic nephropathy (DN) in females with type 1 diabetes (T1D).

rs5498 in the ICAM1 gene was associated with a decreased risk of transplant-related mortality (TRM) (P ≤ 0.02) among both recipients and donors of Allogeneic hematopoietic cell transplant (HCT) [R]. 

The minor allele ''G'' is correlated with  with higher sICAM-1 (soluble Intercellular Adhesion Molecule 1) levels and has been associated with lower risk of asthma [R].

In whites, rs5498 was significantly associated with sICAM-1 (p<0.001) and each of the ''G'' allele was associated with 5% higher sICAM-1 concentration [R]. 

The ''A'' allele increased stepwise from non-diabetic control subjects to type 1 diabetes (T1D) patients without diabetic nephropathy and T1D patients with diabetic nephropathy. ''A'' allele confers susceptibility to the development of T1D [R].

The major allele ''A'' was increased from type 1 diabetes (T1D) patients without diabetic nephropathy (DN) to the patients with DN in females of the GoKinD population. The allele ''G'' is associated with the decreased risk susceptibility in female T1D patients with DN [R].

The ''G'' allele was significantly associated with higher levels of sICAM-1 (soluble Intercellular adhesion molecule-1) [R].

At least one ''G'' allele increases the risk of prostate cancer in men with a family history of prostate cancer (odds ratio = 1.8) [R].

The heterozygosity and positivity for the allele ''G'' were found to be significantly associated with diabetic nephropathy (DN) in female type 1 diabetes (T1D) patients (P = 0.010, OR = 0.633, and P = 0.026, OR = 0.692) [R]. 

A higher prevalence of ''G'' allele carriers (AG + GG) was seen in patients compared to controls (68 vs. 64%, P = 0.399). A synergistic effect of ''G'' allele carrier-state and smoking that had influenced the risk of CAD was observed. Smoking carriers of ''G'' allele compared to non-smoking ''AA'' were more prevalent in CAD group (39.8%) than among controls (13.3%, P < 0.0001, OR 4.81). Moreover, there was also a synergistic effect between ''G'' allele carrier-state and an elevated level of triacylglycerols (TG) (SIM = 1.28) increasing the risk of CAD [R].

The ''G'' allele was associated with increased risk of severe malaria (OR = 1.91; P = 0.02) [R].

The ''G'' allele was associated with increased tumor grade (OR=2.650) and  epithelial ovarian cancer (EOC) risk (OR=1.405). However, the ''G'' allele correlated with EOC survival time in patients whose first-degree relatives (FDRs) suffered from a tumor (p=0.001) [R].

Individuals with the ''G'' allele had a higher risk for oral squamous cell carcinoma (OSCC) [R]. 

The ''A'' allele along with the ''G'' allele of rs1799969 may be protective against brain tumors [R].

The ''A'' is a putative risk predisposing allele for T2D retinopathy and its clinical covariates in Indian population.The AA genotype was seen at a higher frequency in the retinopathy group (p=0.012). The risk for diabetic retinopathy (DR) increased in the presence of AA genotype (OR=1.89-4.82) [R]. 

A decreased frequency of the ''AA'' genotype was observed in the peripheral artery disease (PAD) subjects compared to controls (p=0.06) [R].

The risk of asthma was higher for children carrying the GG genotype (odds ratio = 1.68) than for those with the AA or AG genotypes [R].

A/G genotypes were significantly associated with diabetic nephropathy (DN) [R].

Genotype ''AG'' and ''GG'' were associated with  hepatocellular carcinoma (HCC) risk among smokers [R]. 

The ''GG'' genotype was associated with a higher risk of invasive cancer and precancerous lesions, respectively, but with lower power [R]. 

A>G polymorphism was associated with a significantly increased risk of oral cancer, but with protection from colorectal cancer and melanoma [R].