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TYK2
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs2304256 | |||
| rs280523 | |||
| rs12720356 | |||
| rs2304255 | |||
| rs280497 | |||
| rs12720233 | |||
| rs77477628 | |||
| rs55762744 | |||
| rs763754692 | |||
| rs12720352 | |||
| rs280519 | |||
| rs78899861 | |||
| rs2304237 | |||
| rs770480398 | |||
| rs777227495 | |||
| rs7258015 | |||
| rs11085731 | |||
| rs2230399 | |||
| rs28378712 | |||
| rs12720248 |
Find on This Page
Summary
TYK2 encodes tyrosine kinase 2. Variants of TYK2 may play a role in rheumatoid arthritis by altering the production of inflammatory cytokines.
Lifestyle, diet, and supplement modifications may counteract the effects of these variants by decreasing IL-12 and IL-23.
Protein names
Found in These Blog Articles
GHR Function
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
More Information
The TYK2 gene encodes tyrosine kinase 2, a member of the JAK protein family. Members of the JAK family activate STAT (‘Signal transducer and activator of transcription’) proteins in response to cytokines [R, R].
TYK2 is believed to play a role in the antiviral immune response through the interferon pathways. Mutations that interfere with the function of TYK2 have been associated with immune deficiency [R].
Other variants, however, may be protective against autoimmune diseases like rheumatoid arthritis. Multiple studies across different countries and ethnicities have found that the rare protective allele of one variant was significantly less common in rheumatoid arthritis patients than in the general population. [R, R, R, R].
The TYK2 enzyme regulates multiple cytokine signals, significantly altering the expression of IL-6, IL-10, IL-12, and IL-23, among others. Mice without functional TYK2 have compromised IFN-α, IL-12, and IL-23 pathways, but intact IL-6 and IL-10 pathways [R].
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