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SelfDecode uses the only scientifically validated genetic prediction technology for consumers. Read more
TPD52
SNP Table
Find on This Page
Summary
TPD52 encodes tumor protein D52, and DGAT1 encodes diacylglycerol O-acyltransferase 1. A variant that affects both TPD52 and DGAT1 may play a role in rheumatoid arthritis by altering the response to immunosuppressant drugs and impairing sugar and fat metabolism.
Lifestyle, diet, and supplement modifications may counteract the effects of these variants by correcting metabolism.
Protein names
Found in These Blog Articles
More Information
The TPD52 gene encodes tumor protein D52. We know very little about TPD52 except that it can be used as a biomarker for some forms of cancer and that it has been associated with rheumatoid arthritis [R, R, R, R].
In cancer, lower levels of TPD52 are generally associated with worse outcomes [R].
Variations in TPD52 may affect whether or not certain rheumatoid arthritis treatments work well. In one study, researchers identified TPD52 as one of the rheumatoid arthritis susceptibility genes that might affect response to infliximab, a drug that suppresses the immune system [R, R].
The TPD52 variant that has been associated with rheumatoid arthritis, rs998731, may also affect the expression of another gene called DGAT1. The DGAT1 gene encodes diacylglycerol O-acyltransferase 1 [R, R].
DGAT1 affects the storage and metabolism of sugar and fat. Recently, some studies have found that rheumatoid arthritis patients are less likely to be able to process sugars and fats in a healthy way compared with healthy people [R].
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