From NCBI Gene: Diarrhea 7From UniProt: Diarrhea 7 (DIAR7): A life-threatening disease characterized by severe, intractable, watery diarrhea. [MIM:615863]

     From NCBI Gene: This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol . Activity of this protein may be associated with obesity and other metabolic diseases. [provided by RefSeq, Jul 2013] From UniProt: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.

The following transcription factors affect gene expression:

• PPAR-gamma1
• PPAR-gamma2
• CREB
• deltaCREB
• PPAR-alpha

Enzyme Regulation:

XP620 is a selective DGAT1 inhibitor.

Molecular Function:

• 2-Acylglycerol O-Acyltransferase Activity
• Diacylglycerol O-Acyltransferase Activity
• Retinol O-Fatty-Acyltransferase Activity
• Transferase Activity, Transferring Acyl Groups

Biological Processes:

• Acylglycerol Acyl-Chain Remodeling
• Diacylglycerol Metabolic Process
• Fatty Acid Homeostasis
• Lipid Storage
• Long-Chain Fatty-Acyl-Coa Metabolic Process
• Triglyceride Biosynthetic Process
• Triglyceride Metabolic Process
• Very-Low-Density Lipoprotein Particle Assembly