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TNIP1
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs565044474 | |||
| rs769417545 | |||
| rs52817781 | |||
| rs2233311 | |||
| rs12516176 | |||
| rs12518386 | |||
| rs1862363 | |||
| rs3805433 | |||
| rs2233312 | |||
| rs781300669 | |||
| rs5872185 | |||
| rs2233289 | |||
| rs2233290 | |||
| rs2017638 | |||
| rs4958435 | |||
| rs918499 | |||
| rs138164905 | |||
| rs60454275 | |||
| rs6895271 | |||
| rs113833830 |
Find on This Page
Summary
TNIP1 helps modulate the activity of the inflammatory protein NF-kB by interacting with TNFAIP3. Variants of TNIP1 may play a role in lupus by decreasing the production of TNIP1 (R).
Lifestyle and supplement modifications may counteract the effects of these variants by increasing TNFAIP3 production and suppressing NF-kB.
Protein names
Found in These Blog Articles
More Information
The TNIP1 gene codes for TNFAIP3-interacting protein 1 (TNIP1). TNIP1 is a protein that may suppress the activity of NF-kB, either alone or (as its name suggests) by interacting with TNFAIP3 [R, R, R].
NF-kB is a protein with the potential to stimulate inflammatory protein release, as well as promote the formation of antibodies that recognize the body’s own tissues (autoantibodies). In this manner, NF-kB may play a major role in the development of autoimmune disorders, such as lupus [R, R].
Variants of TNIP1 have been associated with lupus. These variants may decrease the production of TNIP1, which may result in reduced activity of TNFAIP3, activation of NF-kB, inflammatory protein release, and autoantibody formation [R, R, R, R, R, R, R, R, R, R].
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