Summary of TNIP1
The TNIP1 gene encodes TNFAIP3 interacting protein 1 [R].
TNIP1 appears to regulate the activation of NF-kB, which in turn activates many inflammatory pathways. Researchers are interested in the potential link between TNIP1 and autoimmune disease [R].
Variants in TNIP1 have been linked to [R, R, R, R, R]:
- Myasthenia gravis
- Systemic lupus erythematosus
- Systemic sclerosis
- Lupus nephritis
- Psoriasis
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Protein names
Recommended name:
TNFAIP3-interacting protein 1Short name:
VANAlternative name(s):
A20-binding inhibitor of NF-kappa-B activation 1ABIN-1
HIV-1 Nef-interacting protein
Nef-associated factor 1
Naf1
Nip40-1
Virion-associated nuclear shuttling protein
hVAN
- RS10036748 (TNIP1) ??
- RS17728338 (TNIP1) ??
- RS2233278 (TNIP1) ??
- RS2233287 (TNIP1) ??
- RS3762999 (TNIP1) ??
- RS3792783 (TNIP1) ??
- RS4958881 (TNIP1) ??
- RS6889239 (TNIP1) ??
- RS7708392 (TNIP1) ??
- RS960709 (TNIP1) ??
- RS999556 (TNIP1) ??
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Top Gene-Substance Interactions
TNIP1 Interacts with These Diseases
| Disease | Score |
Substances That Increase TNIP1
| Substances | Interaction | Organism | Category |
Substances That Decrease TNIP1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
Biological Processes:
- Myd88-Dependent Toll-Like Receptor Signaling Pathway
- Translation
- Proteolysis
- Defense Response
- Inflammatory Response
- Leukocyte Cell-Cell Adhesion
- Glycoprotein Biosynthetic Process
- Negative Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Negative Regulation Of Viral Genome Replication
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Inflammatory Response
- Negative Regulation Of Erk1 And Erk2 Cascade
- Modulation By Symbiont Of Host I-Kappab Kinase/Nf-Kappab Cascade