Summary of TNIP1
This gene encodes a protein that T plays a role in autoimmunity and tissue homeostasis. Mutations in this gene are associated with arthritis and lupus (R).
The Function of TNIP1
Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.
Protein names
Recommended name:
TNFAIP3-interacting protein 1Short name:
VANAlternative name(s):
A20-binding inhibitor of NF-kappa-B activation 1ABIN-1
HIV-1 Nef-interacting protein
Nef-associated factor 1
Naf1
Nip40-1
Virion-associated nuclear shuttling protein
hVAN
- RS10036748 (TNIP1) ??
- RS17728338 (TNIP1) ??
- RS2233278 (TNIP1) ??
- RS2233287 (TNIP1) ??
- RS3792783 (TNIP1) ??
- RS4958881 (TNIP1) ??
- RS6889239 (TNIP1) ??
- RS7708392 (TNIP1) ??
- RS960709 (TNIP1) ??
- RS999556 (TNIP1) ??
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Top Gene-Substance Interactions
TNIP1 Interacts with These Diseases
| Disease | Score |
Substances That Increase TNIP1
| Substances | Interaction | Organism | Category |
Substances That Decrease TNIP1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. In peripheral blood mononucleocytes, isoform 4 is mainly expressed and isoform 1 and isoform 7 are almost not expressed. Expression of isoform 1 and isoform 7 increases in leukemic cells.
Molecular Function:
Biological Processes:
- Defense Response
- Glycoprotein Biosynthetic Process
- Inflammatory Response
- Leukocyte Cell-Cell Adhesion
- Modulation By Symbiont Of Host I-Kappab Kinase/Nf-Kappab Cascade
- Myd88-Dependent Toll-Like Receptor Signaling Pathway
- Negative Regulation Of Erk1 And Erk2 Cascade
- Negative Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Negative Regulation Of Viral Genome Replication
- Positive Regulation Of Inflammatory Response
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Proteolysis
- Translation