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  3. TNIP1

TNIP1 (TNFAIP3 interacting protein 1)

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Summary of TNIP1

This gene encodes a protein that T plays a role in autoimmunity and tissue homeostasis. Mutations in this gene are associated with arthritis and lupus (R). 

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The Function of TNIP1

Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.

Protein names

Recommended name:

TNFAIP3-interacting protein 1

Short name:

VAN

Alternative name(s):

A20-binding inhibitor of NF-kappa-B activation 1
ABIN-1
HIV-1 Nef-interacting protein
Nef-associated factor 1
Naf1
Nip40-1
Virion-associated nuclear shuttling protein
hVAN

TNIP1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10036748 (TNIP1) ??
  2. RS17728338 (TNIP1) ??
  3. RS2233278 (TNIP1) ??
  4. RS2233287 (TNIP1) ??
  5. RS3792783 (TNIP1) ??
  6. RS4958881 (TNIP1) ??
  7. RS6889239 (TNIP1) ??
  8. RS7708392 (TNIP1) ??
  9. RS960709 (TNIP1) ??
  10. RS999556 (TNIP1) ??

Top Gene-Substance Interactions

TNIP1 Interacts with These Diseases

Disease Score

Substances That Increase TNIP1

Substances Interaction Organism Category

Substances That Decrease TNIP1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • c-Jun
  • NF-kappaB1
  • GATA-3
  • RelA
  • Sox5

Tissue specificity:

Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. In peripheral blood mononucleocytes, isoform 4 is mainly expressed and isoform 1 and isoform 7 are almost not expressed. Expression of isoform 1 and isoform 7 increases in leukemic cells.

Molecular Function:

  • Mitogen-Activated Protein Kinase Binding

Biological Processes:

  • Defense Response
  • Glycoprotein Biosynthetic Process
  • Inflammatory Response
  • Leukocyte Cell-Cell Adhesion
  • Modulation By Symbiont Of Host I-Kappab Kinase/Nf-Kappab Cascade
  • Myd88-Dependent Toll-Like Receptor Signaling Pathway
  • Negative Regulation Of Erk1 And Erk2 Cascade
  • Negative Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Negative Regulation Of Viral Genome Replication
  • Positive Regulation Of Inflammatory Response
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Proteolysis
  • Translation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| virion-associated nuclear-shuttling protein| naf1| A20 binding and inhibitor of NF-kB protein 1| A20-binding inhibitor of NF-kappa B activation| A20-binding inhibitor of NF-kappa-B activation 1| ABIN| ABIN1| ABIN-1| Anapl_09340| AS27_12000| AS28_08128| CB1_000163014| D623_10034767| H920_12024| HIV-1 Nef-interacting protein| I79_005449| M91_14331| M959_08416| MDA_GLEAN10025685| N306_11975| N309_09676| N310_07620| N320_05634| N321_05183| N333_04334| N334_06368| Nef| Nef-associated factor 1| Nef-associated factor 1 SNP| nip40-1| PAL_GLEAN10018771| TNFAIP3-interacting protein 1| TNFAIP3-interacting protein 1-like| UY3_18251| VAN| virion-associated nuclear shuttling protein| Y1Q_015503| Y956_02358| tnip1

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