inflammation & autoimmunity

TNIP1

Inflammatory Protein Suppression in Lupus (TNIP1)

Written by Shany Lahan, MS (Neuroscience) on December 4th, 2020

TNIP1 may help suppress an inflammatory protein… but how might TNIP1 variants increase the risk of lupus? Read more to find out.

Summary

TNIP1 helps modulate the activity of the inflammatory protein NF-kB by interacting with TNFAIP3. Variants of TNIP1 may play a role in lupus by decreasing the production of TNIP1. Lifestyle and supplement modifications may counteract the effects of these variants by increasing TNFAIP3 production and suppressing NF-kB.

TNIP1 and Lupus

The TNIP1 gene codes for TNFAIP3-interacting protein 1 (TNIP1). TNIP1 is a protein that may suppress the activity of NF-kB, either alone or (as its name suggests) by interacting with TNFAIP3 [R, R, R].

NF-kB is a protein with the potential to stimulate inflammatory protein release, as well as promote the formation of antibodies that recognize the body’s own tissues (autoantibodies). In this manner, NF-kB may play a major role in the development of autoimmune disorders, such as lupus [R, R].

Variants of TNIP1 have been associated with lupus. These variants may decrease the production of TNIP1, which may result in reduced activity of TNFAIP3, activation of NF-kB, inflammatory protein release, and autoantibody formation [R, R, R, R, R, R, R, R, R, R].

Your TNIP1 Results for Lupus

SNP Table

variant	genotype	frequency	risk allele
rs10036748
rs6889239
rs7708392

Primary SNP

TNIP1 rs10036748 [R, R]

‘T’ = Higher odds of lupus
‘C’ = Not associated with lupus

Other Important SNPs

TNIP1 rs6889239 [R, R]

‘C’ = Higher odds of lupus
‘T’ = Not associated with lupus

TNIP1 rs7708392 [R, R]

‘C’ = Higher odds of lupus
‘G’ = Not associated with lupus

Recommendations

Lifestyle

Acupuncture

In a study of rats, a form of acupuncture involving electric currents (electroacupuncture) was found to suppress NF-kB activation by increasing the production of TNFAIP3 [R].

Acupuncture may help relieve muscle pain associated with lupus. In a small trial of lupus patients, standard care failed to reduce pain, while a 10-session course of acupuncture reduced pain by at least 30% in the patients who received it [R].

Acupuncture may help manage lupus by increasing the production of TNFAIP3 and suppressing NF-kB.

Supplements

Omega-3 Fatty Acids

Omega-3 fatty acids increased the production of TNFAIP3 in cell- and animal-based studies [R, R].

In 6 clinical trials of patients with lupus, supplementation with 3-20 g omega-3 per day for up to 6 months improved symptoms, fatigue, quality of life, blood vessel function, blood fat profile, inflammatory markers, and oxidative stress [R, R, R, R, R, R].

However, the results are mixed: omega-3 fatty acids were ineffective at improving lupus severity and kidney damage in 4 trials [R, R, R, R].

Omega-3 fatty acids may help manage lupus by increasing TNFAIP3 production.

Zinc

TNFAIP3 requires zinc for its activation, and studies have shown that zinc may even suppress NF-kB by increasing TNFAIP3 production [R, R, R].

People with autoimmune diseases, including lupus, are more likely to have a zinc deficiency than the healthy population. In animals, zinc deprivation worsened the symptoms of autoimmune diseases [R, R].

Zinc is available as a supplement, and the richest dietary sources of zinc include beef, pork, oysters and other seafood [R].

Zinc may help manage lupus by increasing TNFAIP3 production and suppressing NF-kB.

Shany Lahan

MS (Neuroscience)

Shany received her MSc in Neuroscience from Western University.

Prior to joining SelfDecode, Shany conducted research related to Alzheimer’s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode with a mission to help others optimize their health and wellbeing – as well as help them understand the science behind it all.

Disclaimer

The information on this website has not been evaluated by the Food & Drug Administration or any other official medical body. This information is presented for educational purposes only, and may not be used to diagnose or treat any illness or disease.

Also keep in mind that the “Risk Score” presented in this post is based only on a select number of SNPs, and therefore only represents a small portion of your total risk as an individual. Furthermore, these analyses are based primarily on associational studies, which do not necessarily imply causation. Finally, many other (non-genetic) factors can also play a significant role in the development of a disease or health condition — therefore, carrying any of the risk-associated genotypes discussed in this post does not necessarily mean you are at increased risk of developing a major health condition.

Always consult your doctor before acting on any information or recommendations discussed in this post — especially if you are pregnant, nursing, taking medication, or have been officially diagnosed with a medical condition.

More inflammation & autoimmunity blogs

How to Combat Histamine Intolerance Through Genetics (DAO) Are You Genetically Vulnerable to High Brain Histamine, Migraines, or ADHD? (HNMT) How to Tell if You’re Lectin Sensitive Using Your Genetic Data (CNR1) Are You Sensitive to Lectins? (MTHFR) Fight Oxidative Stress, Inflammation, and Brain Fog (PARP1) Is This Gene Causing Your Autoimmune Problems? (PTPN22) Are You Genetically Susceptible to Post-Treatment Lyme? (ABCB1) A Key Genetic Player in Autoimmunity (HLA-B) Is This Inflammation Gene Reducing Your Intelligence? (TNFSF9) Can You Manage Allergies and Asthma by Balancing Methylation? (MTHFR)

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Summary TNIP1 and Lupus Your TNIP1 Results for Lupus

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