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SLC15A4
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs1484934 | |||
| rs34888374 | |||
| rs12816551 | |||
| rs11059924 | |||
| rs33990080 | |||
| rs7974764 | |||
| rs1059312 | |||
| rs12822447 | |||
| rs513831 | |||
| rs5801825 | |||
| rs2291350 | |||
| rs532705951 | |||
| rs10734964 | |||
| rs10734965 | |||
| rs10744389 | |||
| rs10773579 | |||
| rs10773580 | |||
| rs10847693 | |||
| rs10847694 | |||
| rs11059916 |
Find on This Page
Summary
SLC15A4 encodes a protein called solute carrier family 15 member 4. Variants of SLC15A4 may play a role in lupus by increasing the production of inflammatory signals through the toll-like receptors.
Lifestyle, diet, and supplement modifications may counteract the effects of these variants by suppressing TLR signalling.
Protein names
Found in These Blog Articles
More Information
The SLC15A4 gene encodes a protein called solute carrier family 15 member 4. This protein transports the amino acid histidine and some short proteins into cells. Mice without SLC15A4 are unable to produce type 1 interferon and other inflammatory signals that rely on NOD1, TLR7, and TLR9 [R, R].
TLR7 and TLR9 are members of a family of toll-like receptors which also includes TLR4. Toll-like receptors (TLRs) sense the presence of bacteria or viruses and trigger an immune response to protect the body from invading pathogens [R, R, R, R].
Most of the time, when TLRs are working correctly, they specifically target potentially dangerous invaders. However, excessive activation of TLRs may result in a person’s own proteins or DNA being targeted, which in turn may lead to an autoimmune response [R, R].
Given the connection between the toll-like receptors and autoimmune disease, it’s not surprising that variants in SLC15A4 have been linked to lupus [R, R].
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