The Function of TLR7
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
0 users want this gene increased,
0 users want it decreased
Protein names
Recommended name:
Toll-like receptor 7- RS179008 (TLR7) ??
- RS179010 (TLR7) ??
- RS179012 (TLR7) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
Substances That Increase TLR7
| Substances | Interaction | Organism | Category |
Substances That Decrease TLR7
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
Molecular Function:
- Double-Stranded Rna Binding
- Drug Binding
- Receptor Activity
- Single-Stranded Rna Binding
- Sirna Binding
- Transmembrane Signaling Receptor Activity
Biological Processes:
- Cellular Response To Mechanical Stimulus
- Defense Response To Virus
- I-Kappab Phosphorylation
- Inflammatory Response
- Innate Immune Response
- Microglial Cell Activation
- Myd88-Dependent Toll-Like Receptor Signaling Pathway
- Positive Regulation Of Chemokine Production
- Positive Regulation Of Inflammatory Response
- Positive Regulation Of Interferon-Alpha Biosynthetic Process
- Positive Regulation Of Interferon-Beta Biosynthetic Process
- Positive Regulation Of Interferon-Gamma Biosynthetic Process
- Positive Regulation Of Interleukin-6 Production
- Positive Regulation Of Interleukin-8 Biosynthetic Process
- Positive Regulation Of Interleukin-8 Production
- Positive Regulation Of Nf-Kappab Import Into Nucleus
- Regulation Of Protein Phosphorylation
- Toll-Like Receptor 7 Signaling Pathway
- Toll-Like Receptor 9 Signaling Pathway
- Toll-Like Receptor Signaling Pathway