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  3. TLR7

TLR7 (Toll like receptor 7)

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The Function of TLR7

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

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Protein names

Recommended name:

Toll-like receptor 7

TLR7 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS179008 (TLR7) ??
  2. RS179010 (TLR7) ??
  3. RS179012 (TLR7) ??

Top Gene-Substance Interactions

Substances That Increase TLR7

Substances Interaction Organism Category

Substances That Decrease TLR7

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • c-Jun
  • STAT3
  • NF-kappaB1
  • IRF-1
  • STAT1
  • STAT1beta
  • STAT1alpha

Tissue specificity:

Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.

Gene Pathways:

  • Immune System
  • Measles
  • Toll-like receptor signaling pathway
  • Innate Immune System

Molecular Function:

  • Double-Stranded Rna Binding
  • Drug Binding
  • Receptor Activity
  • Single-Stranded Rna Binding
  • Sirna Binding
  • Transmembrane Signaling Receptor Activity

Biological Processes:

  • Cellular Response To Mechanical Stimulus
  • Defense Response To Virus
  • I-Kappab Phosphorylation
  • Inflammatory Response
  • Innate Immune Response
  • Microglial Cell Activation
  • Myd88-Dependent Toll-Like Receptor Signaling Pathway
  • Positive Regulation Of Chemokine Production
  • Positive Regulation Of Inflammatory Response
  • Positive Regulation Of Interferon-Alpha Biosynthetic Process
  • Positive Regulation Of Interferon-Beta Biosynthetic Process
  • Positive Regulation Of Interferon-Gamma Biosynthetic Process
  • Positive Regulation Of Interleukin-6 Production
  • Positive Regulation Of Interleukin-8 Biosynthetic Process
  • Positive Regulation Of Interleukin-8 Production
  • Positive Regulation Of Nf-Kappab Import Into Nucleus
  • Regulation Of Protein Phosphorylation
  • Toll-Like Receptor 7 Signaling Pathway
  • Toll-Like Receptor 9 Signaling Pathway
  • Toll-Like Receptor Signaling Pathway

Drug Bank:

  • Hydroxychloroquine
  • Imiquimod
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_12688| Anapl_16177| AS28_13904| CB1_001960006| D623_10004312| GW7_05279| H920_19328| I79_020406| M91_16098| MDA_GLEAN10014539| N300_02353| N303_05490| N308_12572| N309_00649| N312_10156| N320_08271| N321_11625| N322_02899| N324_05006| N325_00078| N326_10207| N327_10191| N328_12452| N329_11485| N330_00110| N331_00686| N333_02444| N334_05736| N335_12419| N336_12750| N339_11087| N340_04927| N341_00020| PAL_GLEAN10003871| PANDA_003056| RGD1563357| TLR-7| TLR7A| TLR7-like| toll-like receptor 7| toll-like receptor 7-like| toll-like receptor 7-long| TREES_T100007046| UY3_07465| Y956_08374| Z169_11614| tlr7

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