The Function of TLR7
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
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Protein names
Recommended name:
Toll-like receptor 7- RS179008 (TLR7) ??
- RS179010 (TLR7) ??
- RS179012 (TLR7) ??
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Top Gene-Substance Interactions
Substances That Increase TLR7
| Substances | Interaction | Organism | Category |
Substances That Decrease TLR7
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
Molecular Function:
- Double-Stranded Rna Binding
- Single-Stranded Rna Binding
- Receptor Activity
- Transmembrane Signaling Receptor Activity
- Drug Binding
- Sirna Binding
Biological Processes:
- Microglial Cell Activation
- Regulation Of Protein Phosphorylation
- Toll-Like Receptor Signaling Pathway
- Myd88-Dependent Toll-Like Receptor Signaling Pathway
- Inflammatory Response
- I-Kappab Phosphorylation
- Positive Regulation Of Chemokine Production
- Positive Regulation Of Interleukin-6 Production
- Positive Regulation Of Interleukin-8 Production
- Toll-Like Receptor 7 Signaling Pathway
- Toll-Like Receptor 9 Signaling Pathway
- Positive Regulation Of Nf-Kappab Import Into Nucleus
- Positive Regulation Of Interferon-Gamma Biosynthetic Process
- Innate Immune Response
- Positive Regulation Of Interferon-Alpha Biosynthetic Process
- Positive Regulation Of Interferon-Beta Biosynthetic Process
- Positive Regulation Of Interleukin-8 Biosynthetic Process
- Positive Regulation Of Inflammatory Response
- Defense Response To Virus
- Cellular Response To Mechanical Stimulus