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  3. TLR9

TLR9 (Toll like receptor 9)

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The Function of TLR9

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.

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Protein names

Recommended name:

Toll-like receptor 9

Alternative name(s):

CD antigen CD289

TLR9 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS187084 (TLR9) ??
  2. RS352139 (TLR9) ??
  3. RS352140 (TLR9) ??

Top Gene-Substance Interactions

TLR9 Interacts with These Diseases

Disease Score

Substances That Increase TLR9

Substances Interaction Organism Category

Substances That Decrease TLR9

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • c-Jun
  • NF-kappaB1
  • STAT1
  • STAT1beta
  • STAT1alpha

Tissue specificity:

Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.

Gene Pathways:

  • Immune System
  • Signal Transduction
  • Measles
  • Toll-like receptor signaling pathway
  • Tuberculosis
  • Chagas disease (American trypanosomiasis)
  • African trypanosomiasis
  • Malaria

Molecular Function:

  • 1-Phosphatidylinositol-3-Kinase Activity
  • Interleukin-1 Receptor Binding
  • Sirna Binding
  • Transmembrane Signaling Receptor Activity

Biological Processes:

  • Defense Response To Bacterium
  • Defense Response To Gram-Negative Bacterium
  • I-Kappab Phosphorylation
  • Inflammatory Response
  • Innate Immune Response
  • Maintenance Of Gastrointestinal Epithelium
  • Myd88-Dependent Toll-Like Receptor Signaling Pathway
  • Negative Regulation Of Calcium-Transporting Atpase Activity
  • Negative Regulation Of Interleukin-6 Production
  • Negative Regulation Of Interleukin-8 Production
  • Negative Regulation Of Nf-Kappab Transcription Factor Activity
  • Negative Regulation Of Toll-Like Receptor Signaling Pathway
  • Positive Regulation Of Chemokine Production
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Granulocyte Macrophage Colony-Stimulating Factor Production
  • Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Positive Regulation Of Inflammatory Response
  • Positive Regulation Of Interferon-Alpha Biosynthetic Process
  • Positive Regulation Of Interferon-Beta Biosynthetic Process
  • Positive Regulation Of Interferon-Beta Production
  • Positive Regulation Of Interferon-Gamma Biosynthetic Process
  • Positive Regulation Of Interleukin-10 Production
  • Positive Regulation Of Interleukin-12 Production
  • Positive Regulation Of Interleukin-18 Production
  • Positive Regulation Of Interleukin-6 Production
  • Positive Regulation Of Interleukin-8 Production
  • Positive Regulation Of Jnk Cascade
  • Positive Regulation Of Jun Kinase Activity
  • Positive Regulation Of Nf-Kappab Import Into Nucleus
  • Positive Regulation Of Nf-Kappab Transcription Factor Activity
  • Positive Regulation Of Nitric-Oxide Synthase Biosynthetic Process
  • Positive Regulation Of Toll-Like Receptor Signaling Pathway
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Tumor Necrosis Factor Production
  • Regulation Of Cytokine Secretion
  • Response To Molecule Of Bacterial Origin
  • Toll-Like Receptor 9 Signaling Pathway
  • Toll-Like Receptor Signaling Pathway
  • Tumor Necrosis Factor Production

Drug Bank:

  • Chloroquine
  • Hydroxychloroquine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| toll-like receptor 7| CD289| PAL_GLEAN10009272| TIR9| TLR 9| toll-like receptor 9| Toll-like receptor 9 protein| TWF2| twinfilin-2| twinfilin-like protein| UY3_08989| tlr9

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