The Function of TLR9
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.
Protein names
Recommended name:
Toll-like receptor 9Alternative name(s):
CD antigen CD289- RS187084 (TLR9) ??
- RS352139 (TLR9) ??
- RS352140 (TLR9) ??
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Top Gene-Substance Interactions
TLR9 Interacts with These Diseases
| Disease | Score |
Substances That Increase TLR9
| Substances | Interaction | Organism | Category |
Substances That Decrease TLR9
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.
Gene Pathways:
Molecular Function:
- 1-Phosphatidylinositol-3-Kinase Activity
- Interleukin-1 Receptor Binding
- Sirna Binding
- Transmembrane Signaling Receptor Activity
Biological Processes:
- Defense Response To Bacterium
- Defense Response To Gram-Negative Bacterium
- I-Kappab Phosphorylation
- Inflammatory Response
- Innate Immune Response
- Maintenance Of Gastrointestinal Epithelium
- Myd88-Dependent Toll-Like Receptor Signaling Pathway
- Negative Regulation Of Calcium-Transporting Atpase Activity
- Negative Regulation Of Interleukin-6 Production
- Negative Regulation Of Interleukin-8 Production
- Negative Regulation Of Nf-Kappab Transcription Factor Activity
- Negative Regulation Of Toll-Like Receptor Signaling Pathway
- Positive Regulation Of Chemokine Production
- Positive Regulation Of Gene Expression
- Positive Regulation Of Granulocyte Macrophage Colony-Stimulating Factor Production
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Positive Regulation Of Inflammatory Response
- Positive Regulation Of Interferon-Alpha Biosynthetic Process
- Positive Regulation Of Interferon-Beta Biosynthetic Process
- Positive Regulation Of Interferon-Beta Production
- Positive Regulation Of Interferon-Gamma Biosynthetic Process
- Positive Regulation Of Interleukin-10 Production
- Positive Regulation Of Interleukin-12 Production
- Positive Regulation Of Interleukin-18 Production
- Positive Regulation Of Interleukin-6 Production
- Positive Regulation Of Interleukin-8 Production
- Positive Regulation Of Jnk Cascade
- Positive Regulation Of Jun Kinase Activity
- Positive Regulation Of Nf-Kappab Import Into Nucleus
- Positive Regulation Of Nf-Kappab Transcription Factor Activity
- Positive Regulation Of Nitric-Oxide Synthase Biosynthetic Process
- Positive Regulation Of Toll-Like Receptor Signaling Pathway
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Tumor Necrosis Factor Production
- Regulation Of Cytokine Secretion
- Response To Molecule Of Bacterial Origin
- Toll-Like Receptor 9 Signaling Pathway
- Toll-Like Receptor Signaling Pathway
- Tumor Necrosis Factor Production