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GPX1
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs1050450 | |||
| rs1043210477 | |||
| rs1436141275 | |||
| rs200311870 | |||
| rs548384931 | |||
| rs6446261 | |||
| rs747656004 | |||
| rs774884827 | |||
| rs8179169 | |||
| rs1800668 | |||
| rs3811699 | |||
| rs13086611 | |||
| rs13087851 | |||
| rs13090388 | |||
| rs17080528 | |||
| rs1987628 | |||
| rs34588335 | |||
| rs6446264 | |||
| rs67485053 | |||
| rs6809216 |
Summary
GPX1 encodes a member of the glutathione peroxidase family, which contains important antioxidant enzymes and helps detoxify hydrogen peroxide with glutathione, and thereby protect cells against oxidative damage (R). It protects the hemoglobin in red blood cells from oxidative breakdown.
H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of antioxidant balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes.
It is also a selenoprotein, requiring selenium to function.
Associated with risk for breast cancer (R).
Protein names
Found in These Blog Articles
GHR Function
Protects the hemoglobin in erythrocytes from oxidative breakdown.
More Information
Lifestyle & Supplement Interactions
Methods to Increase GPX1 levels:
- Increased intake of Selenium [R].
- Increaased intake of Glutathione.
- Increased intake of NAC.
- Increased intake of Alpha-Lipoic Acid.
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