High Blood Sugar
Anxiety
Gluten Sensitivity
Gut Inflammation
Blood Pressure
IBS
Mood
Insomnia
PTSD
Mood Swings
Overweight
Memory Performance
Sexual Dysfunction
PCOS
Psoriasis
Joint Pain
Attention/ADHD
Chronic Fatigue / Tiredness
Allergies
Asthma
Acne
Tinnitus
Eczema
Food Allergy
Vitamin B6
Vitamin E
Restless Leg Syndrome
Grinding Teeth
Vitamin A
Magnesium
Zinc
Heart Health
Migraines
(High) Cholesterol
Headache
Chronic Pain
Back pain
Shoulder & Neck Pain
Stress
Inflammation
Omega-3 needs
Salt Sensitivity
Endurance
Power performance
Strength
Exercise recovery
Brain Fog
Female Fertility
Longevity
Addiction
Erectile Dysfunction
Male Infertility
MTHFR
Joint Inflammation
GERD
Ulcers
Sleep Apnea
Periodontitis
Varicose Veins
H. pylori
Liver Health
Canker Sores
Gallstones
Kidney Health
Gout
Hair Loss (Male-Pattern Baldness)
Riboflavin
Urticaria
Rosacea
Carpal Tunnel Syndrome
Sinus Congestion
Cavities
Artery Hardening
Vertigo
Vitiligo
Myopia
Indigestion
Excessive Sweating
Testosterone – Males
Yeast infection (Candida)
Endometriosis
Tobacco addiction
Alcohol addiction
Uterine fibroids
Length of menstrual cycle
UTI
OCD
Kidney Stones
Vitamin B12
Vitamin C
Vitamin D
Folate
Iron
Eating Disorders
Bone Health
Hypothyroidism
Hyperthyroidism
Sugar Cravings
Hearing/difficulty problem /Hearing loss
Painful Periods
Palpitations
Hemorrhoids
Hypotension
Bladder Control
Constipation
Appendicitis
Low Blood Sugar
Irregular Periods
Metabolic rate
Visceral fat
Lung Health
Anemia
Calcium
Cognition
Cognitive Decline
Seasonal Low Mood
Vitamin K
Phosphate
HRV
Cluster headaches
Knee Pain
Hip Pain
Selenium
Low back injury
Dyslexia
Cannabis addiction
Histamine Intolerance
Carnitine
Pesticide Sensitivity
Organophosphate Sensitivity
Cadmium
Lead
Melatonin
FSH
T4
T3
High PTH
Potassium
Coenzyme Q10 (CoQ10)
Chromium
Oxalate Sensitivity
Salicylate Sensitivity
Facial Wrinkles
Age Spots
Ligament Rupture (ACL Injury)
Tendon Injury (Tendinopathy)
Omega 6
Omega 6:Omega 3 Ratio
Arachidonic Acid
Oleic Acid
Alpha-Linolenic Acid
EPA
GLA
Linoleic Acid
DHA
Insulin Resistance
Sperm Motility
Homocysteine
C difficile
Pneumonia
EBV Infection
Gastrointestinal Infection
Chronic Bronchitis
Copper
Skin Elasticity
Skin Hydration
Egg allergy
ApoB
GGT
TIBC
Bioavailable Testosterone (Male)
MPV
Chloride
Free T4
Processing Speed
Short-term memory
TMAO
Air pollution sensitivity
Heart Rate
VO2 Max
Flu
Hair graying
Caffeine-Related Sleep Problems
Groin Hernia
Stretch marks
Droopy Eyelids
Strep infection
Dry eyes
Carbohydrate Consumption
Peanut allergy
Heart rate recovery
Muscle recovery
Jaw Disorders
HPV Infection
Acute Bronchitis
Chlamydia
Genital Herpes
Pancreas inflammation
Executive Function
Pyroglutamic acid
Raynaud’s
Liver Scarring
Dandruff
Bioavailable Testosterone (Female)
Shrimp allergy
Haptoglobin
Milk allergy
Beta-Alanine
Taurine
LDL Particle Size
Diarrhea
Snoring
Uric acid
Phenylalanine
Leucine
Glutamine
Valine
Glycine
Alanine
Lysine
Arginine
Histidine
Tyrosine
Cortisol
DHEAS
Insulin
Prolactin
TSH
Lactate
Ketone Bodies
IL-17A (Th17 Dominance)
Creatine Kinase
Neutrophils
Basophils
Eosinophils
Ferritin
ALT
AST
MCV
Hematocrit
RDW
SHBG
Total Protein
Albumin
MCH
Sodium
MCHC
Alkaline Phosphatase
Monocytes
Ghrelin
IL10 (Th2)
IL-6 (Th2 and Th17)
Iodine
Chili Pepper sensitivity
COMT
DRD2 (Dopamine)
Lectin Sensitivity
Thiamine
Biotin
Mold Sensitivity (Foodborne)
Chronic Lyme
BDNF
Glyphosate sensitivity
BPA Sensitivity
Pregnenolone
Luteinizing Hormone (LH)
Growth Hormone
IgA
Molybdenum
Sensitivity to Dairy (IgG Casein)
Telomere Length
Serotonin (5HIAA)
Non-Celiac Gluten Sensitivity (IgG Gliadin)
Manganese
Klotho
Mold Sensitivity (Airborne)
Amylase
Lipase
Low Sperm Count
Tryptophan
Methionine
Glutamate
Proline
Blood Calcium
Hypertriglyceridemia
HDL Cholesterol
HbA1c
Hemoglobin
Total Cholesterol
LDL Cholesterol
IGF1
Fasting Glucose
Bilirubin (total)
White blood cell count
Red blood cell count
Platelets
eGFR
Creatinine
Estradiol
Neuroticism
Sleep Quality
Lactose Intolerance
Saturated fat
Optimal diet
Unsaturated fat
Achilles tendon injury
Deep sleep
Fat
Response to Stress
Leadership
Ankle injury
Creativity
Hoarding
Protein
Optimal Exercise
Knee Injury
Rotator cuff injury
Extraversion
Risk-Taking
Happiness
Daytime Sleepiness
Morningness
Time spent watching TV
Disliking cilantro
Alcohol Sensitivity
Response to Caffeine
Snacking
Weight Regain
Sleep movement
Wearing glasses or contacts
Educational Attainment
Bitter Taste Sensitivity
Agreeableness
Aggression
Conscientiousness
Openness to experience
Physical activity
Caffeine-Related Anxiety
Naps
ERBB3
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs543912694 | |||
| rs2271189 | |||
| rs2271194 | |||
| rs773123 | |||
| rs10783779 | |||
| rs2292238 | |||
| rs10876870 | |||
| rs7971751 | |||
| rs112651994 | |||
| rs1322171934 | |||
| rs138517750 | |||
| rs139267530 | |||
| rs150001629 | |||
| rs150312718 | |||
| rs188955993 | |||
| rs199586304 | |||
| rs2271188 | |||
| rs370221639 | |||
| rs376939275 | |||
| rs55699040 |
Find on This Page
Summary
ERBB3 codes for a protein that may regulate the hair growth cycle by modulating the activity of the MAPK/ERK pathway. A variant of ERBB3 may play a role in alopecia areata by dysregulating ERBB3 production and MAPK/ERK pathway activity. It is also associated with cancer (R).
Lifestyle modifications may counteract the effects of this variant by preventing overactivity of the MAPK/ERK pathway.
Protein names
Found in These Blog Articles
GHR Function
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134).
More Information
The ERBB3 gene codes for erb-b2 receptor tyrosine kinase 3 (ERBB3), a receptor that regulates proliferation, survival, and metabolic pathways within cells [R, R].
One of the pathways regulated by ERBB3 is MAPK/ERK. MAPK/ERK is essential for skin maintenance and the hair growth cycle, in which hair grows within a follicle, detaches from the follicle, and falls out. This pathway may specifically become activated during stages of hair growth and inactivated during stages of hair detachment [R, R].
Interestingly, studies have demonstrated that both over- and underactivity of the MAPK/ERK pathway may perturb the hair growth cycle. It’s possible that this perturbation may contribute to the autoimmune (self-targeting) disorder alopecia areata (spot baldness), in which T cells disrupt active hair growth stages of the hair growth cycle [R, R, R].
A variant of ERBB3 has been associated with alopecia areata. This variant may alter ERBB3 production, resulting in dysregulated MAPK/ERK pathway activity and hair cycle perturbation [R].
Frequently Asked Questions
Unlock Personalized Results And So Much More!
Shipping Worldwide
30-Days Money-Back Guarantee*
HSA/FSA Eligible
Essential Bundle
- 24/7 AI Health Coach
- 1250+ Comprehensive DNA Health Reports
- Personalized Diet, Supplement, & Lifestyle Recommendations
- Lifestyle Risk Assessments
- Unlimited access to Labs Analyzer
Men's Health Month 10% Off
Essential
Bundle
- Everything in essential
- SelfDecode DNA Kit
- Methylation Pathway
- +130 Medical Reports
- 25+ Longevity Screener Risk Assessments
- Odds ratios to evaluate your risk for 25+ medical conditions
- 10-year risk scores to prioritize health conditions
- Lifetime risk scores to plan for long-term health
Men's Health Month 15% Off
Men's Health Month 30% Off
Ultimate Bundle
- Everything in essential+
- SelfDecode DNA Kit
- Medication Check (PGx testing) for 50+ medications
- 40+ Family Planning (Carrier Status) Reports
- Ancestry Percentages
- Mitochondrial Ancestry
* SelfDecode DNA kits are non-refundable. If you choose to cancel your plan within 30 days you will not be refunded the cost of the kit.
We will never share your data
We follow HIPAA and GDPR policies
We have World-Class Encryption & Security
Rated 4.7/5 from 750+ reviews
200,000+ users, 2,000+ doctors & 80+ businesses
SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode strongly encourages those who use our service to consult and work with an experienced healthcare provider as our services are not to replace the relationship with a licensed doctor or regular medical screenings.