Summary of ERBB3
This gene encodes a protein that works with other receptors to bind ligands. It is associated with cancer (R).
The Function of ERBB3
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134).
Protein names
Recommended name:
Receptor tyrosine-protein kinase erbB-3Alternative name(s):
Proto-oncogene-like protein c-ErbB-3Tyrosine kinase-type cell surface receptor HER3
- RS10783779 (ERBB3) ??
- RS11171739 (ERBB3) ??
- RS12580100 (ERBB3) ??
- RS2292239 (ERBB3) ??
- RS34379766 (ERBB3) ??
- RS7312770 (ERBB3) ??
- RS877636 (ERBB3) ??
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Top Gene-Substance Interactions
ERBB3 Interacts with These Diseases
Disease | Score |
Substances That Increase ERBB3
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Substances That Decrease ERBB3
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Advanced Summary
From NCBI Gene: Lethal congenital contracture syndrome 2From UniProt: Lethal congenital contracture syndrome 2 (LCCS2): A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS2 patients manifest craniofacial/ocular findings, lack of hydrops, multiple pterygia, and fractures, as well as a normal duration of pregnancy and a unique feature of a markedly distended urinary bladder (neurogenic bladder defect). The phenotype suggests a spinal cord neuropathic etiology. [MIM:607598]
From NCBI Gene: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008] From UniProt: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134).
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Epithelial tissues and brain.
Gene Pathways:
Developmental stage:
Overexpressed in a subset of human mammary tumors.
Molecular Function:
- Atp Binding
- Growth Factor Binding
- Neuregulin Binding
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
- Protein Heterodimerization Activity
- Protein Homodimerization Activity
- Protein Tyrosine Kinase Activator Activity
- Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Transmembrane Signaling Receptor Activity
- Identical Protein Binding
Biological Processes:
- Cranial Nerve Development
- Endocardial Cushion Development
- Erbb2 Signaling Pathway
- Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
- Heart Development
- Mapk Cascade
- Negative Regulation Of Cell Adhesion
- Negative Regulation Of Neuron Apoptotic Process
- Negative Regulation Of Secretion
- Negative Regulation Of Signal Transduction
- Neuron Apoptotic Process
- Peripheral Nervous System Development
- Phosphatidylinositol 3-Kinase Signaling
- Phosphatidylinositol-Mediated Signaling
- Positive Regulation Of Calcineurin-Nfat Signaling Cascade
- Positive Regulation Of Cardiac Muscle Tissue Development
- Positive Regulation Of Gene Expression
- Positive Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Positive Regulation Of Protein Tyrosine Kinase Activity
- Regulation Of Cell Motility
- Regulation Of Cell Proliferation
- Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Schwann Cell Differentiation
- Signal Transduction
- Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
- Wound Healing