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AFF3
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs62150272 | |||
| rs1194777006 | |||
| rs11900482 | |||
| rs4850920 | |||
| rs4851252 | |||
| rs72819181 | |||
| rs73966422 | |||
| rs4851266 | |||
| rs199557232 | |||
| rs201754690 | |||
| rs13019124 | |||
| rs70940197 | |||
| rs10496346 | |||
| rs11695996 | |||
| rs12615145 | |||
| rs13010010 | |||
| rs7597861 | |||
| rs6750720 | |||
| rs75371288 | |||
| rs12996621 |
Find on This Page
Summary
The AFF3 gene stimulates white blood cells to increase inflammation and TNF-alpha levels, paving the way to rheumatoid arthritis. Specific gene variants may increase AFF3 activity and correlate with higher odds of rheumatoid arthritis.
Protein names
Found in These Blog Articles
GHR Function
Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.
More Information
The AFF3 gene controls the activity of immune cells involved in inflammation [R].
Autoimmune inflammation is a culprit behind rheumatoid arthritis, TNF-alpha being the key inflammatory marker. Many treatment options for rheumatoid arthritis aim at blocking TNF-alpha [R].
Scientists are still studying the exact role of AFF3 variants in rheumatoid arthritis. According to one paper, they may stimulate the inflammatory response of white blood cells, resulting in higher levels of TNF-alpha and other inflammatory proteins [R, R].
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