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UBE2E2

The Relationship Between Protein Breakdown & Elevated Blood Sugar (UBE2E2)

Written by Shany Lahan, MS (Neuroscience) on October 19th, 2020

The UBE2E2 gene is involved in protein breakdown. Read more to learn how variants of UBE2E2 may elevate blood sugar.

Summary

UBE2E2 codes for a protein that’s involved in the breakdown of other proteins. Variants of UBE2E2 may play a role in elevated blood sugar by increasing the breakdown of a receptor required for the release of a blood sugar-regulating hormone. Diet and supplement modifications may counteract the effects of these variants by increasing production of the protein that binds to this receptor.

UBE2E2 and Blood Sugar

Proteins are essential to many biological processes in the human body. For proteins to function properly, they must be folded into precise 3D shapes by the cells that created them.

If a protein becomes misfolded, damaged, or is no longer needed, it can be broken down by a complex of proteins called the proteasome [R].

Ubiquitin is a protein well-known to regulate the breakdown of other proteins. Upon its attachment, ubiquitin can target misfolded, damaged, or unnecessary proteins to the proteasome for breakdown [R].

The UBE2E2 gene codes for ubiquitin-conjugating enzyme E2 E2. This enzyme is involved in ubiquitination: the attachment of ubiquitin to proteins [R].

Proteins that can undergo ubiquitination include the GIP receptor. GIP is a protein that can stimulate the release of insulin, a blood sugar-regulating hormone, in response to elevated blood sugar levels. For GIP to exert this function, it must bind to its receptor on the surface of pancreatic cells [R].

Variants of UBE2E2 have been associated with elevated blood sugar and type 2 diabetes. These variants may increase production or activity of ubiquitin-conjugating enzyme E2 E2, which may result in increased ubiquitination of the GIP receptor [R, R].

This would result in increased breakdown of the GIP receptor, reduced function of GIP, decreased release of insulin, and elevated blood sugar levels.

Your UBE2E2 Results for Blood Sugar

SNP Table

variant	genotype	frequency	risk allele
rs1496653
rs7612463

Primary SNP:

UBE2E2 rs1496653

‘A’ = Increased risk of elevated blood sugar
‘G’ = Not associated with blood sugar

Other Important SNPs:

UBE2E2 rs7612463

‘C’ = Increased risk of elevated blood sugar
‘A’ = Not associated with blood sugar

Recommendations

Diet

Soy

A meta-analysis linked a high intake of soy to a 77% lower risk of developing type 2 diabetes in women and Asian populations. Another meta-analysis restricted the protective effects of soy to certain products, such as tofu, soy protein, and soy isoflavones [R, R].

In people with type 2 diabetes, soy products (especially soy protein) modestly improved fasting blood sugar and insulin resistance [R, R].

In a clinical trial focused on pregnant women with diabetes, soy protein similarly improved blood sugar levels and insulin resistance [R].

Two trials focused on healthy individuals found that soy significantly increased production of GIP [R, R].

Soy may lower blood sugar levels by increasing production of GIP.

Olive Oil

Olive oil consumption was found to reduce the risk of type 2 diabetes by 16%. The Mediterranean diet, which suggests that olive oil should be one’s main source of fat, has been shown to improve blood sugar control [R, R].

In a clinical trial of overweight and diabetic individuals, olive oil consumption significantly reduced fasting blood sugar. In another trial focused on older adults with diabetes, an olive oil-containing diet prevented them from losing their eyesight [R, R].

Olive oil was found to stimulate production of GIP in numerous studies [R, R, R].

Olive oil consumption may lower blood sugar levels by increasing production of GIP.

Supplements

Whey Protein

In individuals with type 2 diabetes, whey protein taken during a meal increased the response to insulin and significantly decreased blood sugar levels [R].

It has been suggested that those struggling to maintain a normal blood sugar level can consume whey protein before a high-carbohydrate meal, to reduce blood sugar levels after the meal [R, R].

A randomized controlled trial found that whey protein significantly increased production of GIP in diabetic individuals. A similar result was found in a randomized controlled trial focused on healthy individuals. However, the beneficial effect of whey protein on healthy individuals was greater in older adults, in comparison to younger adults [R, R].

Whey protein may lower blood sugar levels by increasing production of GIP.

Shany Lahan

MS (Neuroscience)

Shany received her MSc in Neuroscience from Western University.

Prior to joining SelfDecode, Shany conducted research related to Alzheimer’s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode with a mission to help others optimize their health and wellbeing – as well as help them understand the science behind it all.

Disclaimer

The information on this website has not been evaluated by the Food & Drug Administration or any other official medical body. This information is presented for educational purposes only, and may not be used to diagnose or treat any illness or disease.

Also keep in mind that the “Risk Score” presented in this post is based only on a select number of SNPs, and therefore only represents a small portion of your total risk as an individual. Furthermore, these analyses are based primarily on associational studies, which do not necessarily imply causation. Finally, many other (non-genetic) factors can also play a significant role in the development of a disease or health condition — therefore, carrying any of the risk-associated genotypes discussed in this post does not necessarily mean you are at increased risk of developing a major health condition.

Always consult your doctor before acting on any information or recommendations discussed in this post — especially if you are pregnant, nursing, taking medication, or have been officially diagnosed with a medical condition.

More blood sugar control blogs

Are You At Risk for Insulin Resistance and Diabetic Complications? (FOXO1) A Surprising Player in Obesity and Diabetes (PEMT) The Role Of Amino Acids In Diet, Obesity, & Diabetes (PPM1K) The Link Between Diabetes and High-Carb Foods (TCF7L2) How An Insulin Gene Influences Diet and Blood Sugar (GIPR) How A Zinc Gene Affects Blood Sugar (SLC30A8) Does This Gene Influence Your Risk of Obesity and Diabetes? (UCP3) Genetics of Inflammation, Obesity & Insulin Resistance (TNF) Does This Gene Influence Your Risk of Obesity and Diabetes? (UCP2) Can This Gene Influence Your Sugar Eating Habits? (SLC2A2)

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The Relationship Between Protein Breakdown & Elevated Blood Sugar (UBE2E2)

Summary

UBE2E2 and Blood Sugar

Your UBE2E2 Results for Blood Sugar

SNP Table

Recommendations

Diet

Soy

Olive Oil

Supplements

Whey Protein

Disclaimer

More blood sugar control blogs

Content

Unlock Personalized Results And So Much More!

Essential Bundle

Essential

Bundle

Ultimate Bundle

Limited Time Offer 25% Off

Individual DNA Reports

Methylation Pathway - MTHFR Test

Histamine Intolerance DNA Pathway Report

Gut Health, Digestion & IBS DNA Report

Autoimmune Disease Risk & Prevention DNA Report

See all reports

Policies

About

Navigation

Health reports