Ask which DNA test has the most reports and you get a bidding war: 150, 200, more. It is almost the wrong question. A “report” can be one variant and a sentence, or a whole-genome polygenic score, and those are not the same product wearing different numbers. SelfDecode produces 1,500-plus from a single sample, more than any company we have found, but the count only means something next to what sits underneath it.
Where the 1,500+ come from
All 1,500+ reports come from the same genome. They are the most comprehensive set by type in the industry, including:
- The most comprehensive pharmacogenomics and carrier-status reports available.
- Nutrigenomics, pathway analysis, and HLA typing.
- Mitochondrial variants, high-risk (pathogenic) variants, and rare-variant analysis beyond the ACMG list.
- 1,500+ polygenic risk scores spanning your whole genome.
All 81 genes on the ACMG SF v3.2 actionable-findings list are covered (BRCA1, BRCA2, Lynch syndrome, familial hypercholesterolemia, hypertrophic cardiomyopathy, long-QT, and the rest). About 1 to 3% of adults carry a clinically significant variant in one. And because every report sits on one unified platform with one editorial standard, you are not stitching together a grab-bag of third-party apps with inconsistent methods.
Why report count alone is a trap
Two numbers can look similar and mean completely different things. A “report” that reads a single variant and prints a sentence is not the same as a polygenic risk score built across your whole genome and validated in peer review. Some competitors pad their counts with the former. So the real questions are: are these real reports, and is the data underneath them clinical-grade. SelfDecode’s answer is yes on both, which is the part a raw number does not show.
Comparison chart
| Company | Reports | Data underneath | One editorial standard? |
| SelfDecode | 1,500+ | Clinical-grade WGS (or imputed upload) | Yes |
| Dante Labs | 200+ | WGS, depth issues reported | Unclear |
| 23andMe | 150+ | Genotyping array | Yes, but array-limited |
| tellmeGen | 130+ | Uploaded/array data + imputation | Yes, but no validated PRS |
| Nucleus | Dozens of conditions | Good WGS, thin analysis | No multi-omics |
How the others stack up
23andMe. Markets 150+ reports total: 95+ health-condition reports, 30+ traits, plus carrier and wellness reports and 4,500+ ancestry regions. All of it sits on a genotyping array, so even the strong ancestry product cannot reach the depth whole-genome reports require. SelfDecode’s 1,500+ is roughly ten times the report count, on far deeper data.
Dante Labs. Markets 200+ reports, but we found no peer-reviewed PRS validation behind them. A larger-than-23andMe report count does not, on its own, establish that the underlying scores are accurate.
tellmeGen. Offers 130+ reports including health conditions and medication compatibility, generated from uploaded or array data via imputation. Useful breadth, but no published, validated polygenic risk scores behind it.
Nucleus. Sequences genuinely well, but the analysis is thin: essentially ACMG findings plus basic carrier screening plus polygenic scores (for a few dozen conditions) with no peer-reviewed validation, and no multi-omics or intelligent recommendations. Strong sequencing, narrow output.
FAQ
Which DNA test has the most reports?
Of the consumer companies we have found, SelfDecode has the most, with 1,500+ health, trait, and condition reports from a single sample. 23andMe markets 150+ and Dante Labs 200+, both on data that is either less complete or lacks published validation.
Do I need to re-sequence to get more reports?
No. With SelfDecode, all 1,500+ reports come from the same genome, and new reports are added over time at no extra sequencing cost, so your one sample keeps generating insights.
Is a higher report count always better?
Only if the reports are real and the data is good. Some companies pad counts with single-variant “reports.” The honest measure is breadth and depth together: how many genuine reports, built on what quality of sequencing.
How many of these reports are actually actionable?
Many. SelfDecode pairs reports with 20,000+ personalized recommendations and covers all 81 ACMG actionable-findings genes, so findings connect to concrete next steps rather than ending at a number.
See the full library
Browse what 1,500+ reports actually covers across 35+ health categories, or upload data you already have to unlock the library without re-sequencing.
Part of the Why Choose SelfDecode comparison. See also: The most comprehensive DNA health reports and How much does SelfDecode cost?.
