rs7528684 is a SNP of the FCRL3 gene. It is significantly associated with autoimmune diseases (ADs).

rs7528684 (no reported alleles) was significantly associated with sudden sensorineural hearing loss (SSNHL) in a Chinese Han population [R]. 

The ''G'' allele associated with Systemic lupus erythamosus (SLE) and rheumatoid arthritis (RA) risk [R].

The ''AA'' genotype was associated with a reduced risk of Graves' disease (GD) [R]. 

Patients with ulcerative colitis (UC) by human leukocyte antigen (HLA) showed a significant increase in heterozygous AG genotype (AG vs AA+GG, P= 0.0027, odds ratio = 3.6) [R].

G/A was associated with autoimmune thyroid disease (AITD) and systemic lupus erythematosus (SLE) [R].  

A positive association was found between the ''AA' genotype and the risk of endometriosis development. Moreover, a progression of the disease risk was observed according to the presence of one or two copies of risk allele ''G'' (OR = 2.14, OR = 3.25, and OR = 6.0, respectively for genotypes AA, GA and GG) [R].

The ''G'' allele was associated with Graves' disease (GD) risk [R].

The AG, AA+AG genotypes contributed to a lower risk of human autoimmune diseases (ADs), compared with the GG carriers (OR = 0.91; OR = 0.91) [R].

 

rs7528684

Parent Gene: FCRL2, FCRL3

Importance: 2
Less common allele: A = 45%
More common allele: G = 55%
My Genotype: Log In
Risk Allele: T

Disease/Trait: Type I Diabetes Mellitus

The T allele of rs7528684 is reported to be associated with Type I Diabetes Mellitus (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Insulinoma-associated antigen 2 autoantibody levels in type 1 diabetes.

Disease/Trait: Autoantibody Measurement

The T allele of rs7528684 is reported to be associated with Autoantibody Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Insulinoma-associated antigen 2 autoantibody levels in type 1 diabetes.