Mechanism:

The Minor "G" allele is associated with:

  • People who produce more MAO-A protein (G or GG) aren't as affected by the placebo effect (R).
  • Increased outward anger in females and aggression in males.

Monoamine oxidase A degrades serotonin, dopamine, epinephrine, and norepinephrine. The G allele encodes for the higher activity form of the enzyme. Subjects with major depressive disorder with the highest activity form of the enzyme (G or G/G) had a significantly lower magnitude of placebo response.

rs6323

Parent Gene: MAOA

Importance: 4
Less common allele: G = 38%
More common allele: T = 62%
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