The Minor "C" allele is associated with:

  • More likely to be diagnosed with obsessive-compulsive personality disorder (OCD), especially in males [R].
  • Poor performance in executive function (CC) [R].
  • Higher rates of cognitive impairment in HIV-positive methamphetamine users [R].
  • Better results from antipsychotic (olanzapine) in schizophrenic patients [R].

The Major "T" allele is associated with:

  • Lower rates of cognitive impairment in HIV-positive methamphetamine users [R].
  • Decreased risk of Parkinsons disease in white Hispanics [R].

This SNP is associated with (unknown which alleles):

  • Prefrontal cognition [R]
  • Nicotine dependence [R]
  • Smoking cessation with treatment [R].
  • Alcohol dependence [R].
  • Early onset heroin dependence [R].
  • Tardive dyskinesia in schizophrenic individuals [R] [R].
  • Schizophrenia (United States and India) [R]. No schizophrenia association in Han Chinese [R].
  • Lower risk of schizophrenia [R] [R] - This article describes findings that explain why Rs6280 seems to always be linked to schizophrenia, but upon closer inspection, is not actually linked.

rs6280

Parent Gene: DRD3

Importance: 3
Less common allele: C = 49%
More common allele: T = 51%
My Genotype: Log In