Mechanism:

  • G (minor) allele= Decreased levels of D2 protein [R].
  • C (major) allele= Normal levels of D2 protein [R].

The G (minor) allele is associated with:

  • Possible increased risk of alcohol abuse [R].
  • Increased risk of Tourette’s syndrome [R].
  • Decreased cognitive recovery after 6 months of a brain injury or brain trauma [R].
  • Worse executive function and language fluency after brain injury [R].
  • Better response to olanzapine (antipsychotic) in women [R].

The C (major) allele is associated with:

  • CC= Increased cognitive recovery after 6 months of a brain injury or brain trauma [R].
  • Better executive function and language fluency after brain injury [R].
  • Possible decreased risk of alcohol abuse [R].
  • Increased prolactin produced in women treated with the antipsychotic olanzapine [R].
  • Decreased risk of Tourette’s syndrome [R].

rs6279

Parent Gene: DRD2

Importance: 3
Less common allele: G = 48%
More common allele: C = 52%
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