The C (minor) allele is associated with:

C = Bad version = predictive of APOE4

  • rs429358(C;C) + rs7412 (C;C) = APOE4/APOE4 (Bad) = 12x for late-onset Alzheimer's and 61x for early-onset disease [R].
  • rs429358(C;T) + rs7412 (C;C) = APOE4/APOE3 (Bad) = >3x increased risk for Alzheimer's; 1.4x increased risk for heart disease  [R].
  • rs429358(T;T) + rs7412 (C;C) = APOE3/APOE3 (Good)

If the allele of this SNP is "C" and the same chromosome also harbors the rs7412 "C" allele, the combination is known as an APOE-ε4 allele. The APOE-ε4 allele has a strong influence on the risk of Alzheimer's disease.

Many studies have estimated the level of risk, and it varies depending on age, sex, ethnicity, and other factors. One meta-analysis estimated the odds ratios for homozygous rs429358(C;C) individuals compared to the more common ApoE3/ApoE3 homozygotes to be 12x for late-onset Alzheimer's and 61x for early-onset disease [R].

Meta-analyses have also supported the association between the APOE-ε4 allele and somewhat increased risk for heart disease, with an odds ratio of 1.42 (CI: 1.26 - 1.61) [R].

The C allele is also reported to be associated with increased levels of physical activity [R

rs429358

Parent Gene: APOE

Importance: 5
Less common allele: C = 15%
More common allele: T = 85%
My Genotype: Log In
Risk Allele: T, C, C, C, C, C, T

Disease/Trait: High Density Lipoprotein Cholesterol Measurement

The T allele of rs429358 is reported to be associated with High Density Lipoprotein Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with HDL cholesterol.

Disease/Trait: Lewy Body Dementia Measurement

The C allele of rs429358 is reported to be associated with Lewy Body Dementia Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Lewy body disease (Ordinal I).

Disease/Trait: Lewy Body Dementia

The C allele of rs429358 is reported to be associated with Lewy Body Dementia (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Lewy body disease (Ordinal I).

Disease/Trait: Lewy Body Dementia Measurement

The C allele of rs429358 is reported to be associated with Lewy Body Dementia Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Lewy body disease (Ordinal II).

Disease/Trait: Lewy Body Dementia

The C allele of rs429358 is reported to be associated with Lewy Body Dementia (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Lewy body disease (Ordinal II).

Disease/Trait: T-Tau Measurement

rs429358 is associated with T-tau Measurement (R) . It is reported to association with Alzheimer's disease biomarkers (AB1-42, p-tau181p, p-tau181p/AB1-42, t-tau/AB1-42). No specific risk allele was identified in the study.

Disease/Trait: Alzheimers Disease

rs429358 is associated with Alzheimers Disease . It is reported to association with Alzheimer's disease biomarkers (AB1-42, p-tau181p, p-tau181p/AB1-42, t-tau/AB1-42). No specific risk allele was identified in the study.

Disease/Trait: Beta-Amyloid 1-42 Measurement

rs429358 is associated with Beta-amyloid 1-42 Measurement (R) . It is reported to association with Alzheimer's disease biomarkers (AB1-42, p-tau181p, p-tau181p/AB1-42, t-tau/AB1-42). No specific risk allele was identified in the study.

Disease/Trait: P-Tau Measurement

rs429358 is associated with P-tau Measurement (R) . It is reported to association with Alzheimer's disease biomarkers (AB1-42, p-tau181p, p-tau181p/AB1-42, t-tau/AB1-42). No specific risk allele was identified in the study.

Disease/Trait: Neuroimaging Measurement

rs429358 is associated with Neuroimaging Measurement (R) . It is reported to association with Brain imaging (multiple phenotypes). No specific risk allele was identified in the study.

Disease/Trait: Cerebral Amyloid Deposition Measurement

The C allele of rs429358 is reported to be associated with Cerebral Amyloid Deposition Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cerebral amyloid deposition positivity (PET imaging).

Disease/Trait: Lewy Body Dementia Measurement

The C allele of rs429358 is reported to be associated with Lewy Body Dementia Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Lewy body disease (Case/control).

Disease/Trait: Lewy Body Dementia

The C allele of rs429358 is reported to be associated with Lewy Body Dementia (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Lewy body disease (Case/control).

Disease/Trait: Alzheimers Disease

The C allele of rs429358 is reported to be associated with Alzheimers Disease . Your genotype was not identified for this SNP so we are unable to comment on your association with Alzheimer's disease biomarkers (Cortical Ab).

Disease/Trait: Amyloid-Beta Measurement

The C allele of rs429358 is reported to be associated with Amyloid-beta Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Alzheimer's disease biomarkers (Cortical Ab).

Disease/Trait: Alzheimers Disease

rs429358 is associated with Alzheimers Disease . It is reported to have a 0.4 unit decrease on Cerebrospinal AB1-42 levels in Alzheimer's disease dementia. No specific risk allele was identified in the study.

Disease/Trait: Beta-Amyloid 1-42 Measurement

rs429358 is associated with Beta-amyloid 1-42 Measurement (R) . It is reported to have a 0.4 unit decrease on Cerebrospinal AB1-42 levels in Alzheimer's disease dementia. No specific risk allele was identified in the study.

Disease/Trait: Wet Macular Degeneration

rs429358 is associated with Wet Macular Degeneration (R) . It is reported to increased association with Advanced age-related macular degeneration (EA). No specific risk allele was identified in the study.

Disease/Trait: Age-Related Macular Degeneration

rs429358 is associated with Age-related Macular Degeneration (R) . It is reported to increased association with Advanced age-related macular degeneration (EA). No specific risk allele was identified in the study.

Disease/Trait: Atrophic Macular Degeneration

rs429358 is associated with Atrophic Macular Degeneration . It is reported to increased association with Advanced age-related macular degeneration (EA). No specific risk allele was identified in the study.

Disease/Trait: Cerebral Amyloid Deposition Measurement

The T allele of rs429358 is reported to be associated with Cerebral Amyloid Deposition Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cerebral amyloid deposition (PET imaging).

Disease/Trait: Cognitive Decline

rs429358 is associated with Cognitive Decline (R) . It is reported to have a 0.01 unit decrease on Cognitive decline (age-related). No specific risk allele was identified in the study.

Disease/Trait: Neuroimaging Measurement

rs429358 is associated with Neuroimaging Measurement (R) . It is reported to association with Brain imaging (grey matter density of the right hippocampus). No specific risk allele was identified in the study.

Disease/Trait: Blood Protein Measurement

rs429358 is associated with Blood Protein Measurement . It is reported to association with Blood protein levels (EA, Apolipoprotein E). No specific risk allele was identified in the study.