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SelfDecode uses the only scientifically validated genetic prediction technology for consumers. Read more
rs3918242
Chromosome
: 20 , Position: 46007337
Most conditions are affected by anywhere from hundreds to millions of
genetic variants (SNPs). A single SNP usually has a minor contribution to
a person’s overall genetic risk for a certain condition. That is why you
shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to
determine polygenic risk scores (PRSs), which are the basis of most health
reports.
Reference Allele: C
Alternative Alleles:
T
Summary
This SNP increases gene production of MMP-9 and was associated with severity of heart hardening of the arteries.
] Matrix metalloproteinase-9 gene polymorphisms in nasal polyposis
[PMID 21244504] Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration
[PMID 21437990] Functional polymorphism of matrix metalloproteinase-9 (MMP-9) gene and response to lithium prophylaxis in bipolar patients
[PMID 21717058] Update analysis of studies on the MMP-9 -1562 C>T polymorphism and cancer risk
[PMID 22107133] Elevated plasma matrix metalloproteinase-9 protein and its gene polymorphism in patients with community-acquired pneumonia
[PMID 16356191] Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study.
[PMID 17346338] Matrix Metalloproteinase-9 (MMP-9) polymorphisms in patients with cutaneous malignant melanoma.
[PMID 18512818] Association of a nonsynonymous single-nucleotide polymorphism of matrix metalloproteinase 9 with giant cell arteritis.
[PMID 18802702] Association of (-1,607) 1G/2G polymorphism of matrix metalloproteinase-1 gene with knee osteoarthritis in the Turkish population (knee osteoarthritis and MMPs gene polymorphisms).
[PMID 18805939] Functional genetic polymorphisms and female reproductive disorders: part II–endometriosis.
[PMID 19664242] Functional polymorphisms in matrix metalloproteinases -1, -3, -9 and -12 in relation to cervical artery dissection.
[PMID 20078883] Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population.
[PMID 21161369] Current evidence on the relationship between four polymorphisms in the matrix metalloproteinases (MMP) gene and breast cancer risk: a meta-analysis.
[PMID 21455563] Analysis of matrix metalloproteinase-9 gene polymorphism -1562 C/T in patients suffering from systemic sclerosis with and without ulcers.
[PMID 21844877] Matrix metalloproteinase-9 genetic variations affect MMP-9 levels in obese children.
[PMID 22304569] Functional polymorphism located in mmp-9 gene promoter is strongly associated with obesity.
[PMID 23257253] Expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in recurrent chronic rhinosinusitis with nasal polyposis
[PMID 23734748] Association of genes of protease-antiprotease balance pathway to lung function and emphysema subtypes
[PMID 23813847] The association of genetic variants of matrix metalloproteinases with abdominal aortic aneurysm: a systematic review and meta-analysis
[PMID 23819814] Association of Genetic Polymorphisms in Matrix Metalloproteinase-9 and Coronary Artery Disease in Chinese Han Population: A Case-Control Study
[PMID 23819551] Genetic polymorphisms in matrix metalloproteinases (MMPs) and tissue inhibitors of MPs (TIMPs), and bladder cancer susceptibility
[PMID 24043671] A Functional Single Nucleotide Polymorphism -1562C>T in the Matrix Metalloproteinase-9 Promoter Is Associated With Type 2 Diabetes and Diabetic Foot Ulcers
[PMID 24291031] Association of APOE, GCPII and MMP9 polymorphisms with common diseases and lipid levels in an older adult/elderly cohort
[PMID 24357512] Gelatinase B (-1562C/T) polymorphism in tumor progression and invasion of breast cancer
[PMID 23010359] Functional matrix metalloproteinase (MMP)-9 genetic variants modify the effects of hemodialysis on circulating MMP-9 levels.
[PMID 23274712] Genetic polymorphisms and the risk of myocardial infarction in patients under 45 years of age.
[PMID 25738347] MMP-9 -1562 C>T () Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions
[PMID 26013370] Matrix Metalloproteinase-9 Polymorphism 1562 C > T () Associated with Protection Against Placental Malaria
[PMID 26754027] Genetic polymorphisms in MMP 2, 3 and 9 genes and the susceptibility of osteosarcoma in a Chinese Han population.
- One T allele=1.14X increased risk for heart attack (p=0.06) [R]
- TT=1.33X increased risk for heart attack (p=0.19)[R]
- One T= 9.1X increased breast cancer risk for whites and 3.6X increased breast cancer risk for mixed ethnicities [R]
- T=increased blood pressure and aortic stiffness in a high blood pressure population (R).
- T allele= increased plaque instability through increased degradation of the cellular structural support web (ECM).
- Has been associated with heart failure (HF) and overall risk of dying (R).
] Matrix metalloproteinase-9 gene polymorphisms in nasal polyposis
[PMID 21244504] Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration
[PMID 21437990] Functional polymorphism of matrix metalloproteinase-9 (MMP-9) gene and response to lithium prophylaxis in bipolar patients
[PMID 21717058] Update analysis of studies on the MMP-9 -1562 C>T polymorphism and cancer risk
[PMID 22107133] Elevated plasma matrix metalloproteinase-9 protein and its gene polymorphism in patients with community-acquired pneumonia
[PMID 16356191] Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study.
[PMID 17346338] Matrix Metalloproteinase-9 (MMP-9) polymorphisms in patients with cutaneous malignant melanoma.
[PMID 18512818] Association of a nonsynonymous single-nucleotide polymorphism of matrix metalloproteinase 9 with giant cell arteritis.
[PMID 18802702] Association of (-1,607) 1G/2G polymorphism of matrix metalloproteinase-1 gene with knee osteoarthritis in the Turkish population (knee osteoarthritis and MMPs gene polymorphisms).
[PMID 18805939] Functional genetic polymorphisms and female reproductive disorders: part II–endometriosis.
[PMID 19664242] Functional polymorphisms in matrix metalloproteinases -1, -3, -9 and -12 in relation to cervical artery dissection.
[PMID 20078883] Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population.
[PMID 21161369] Current evidence on the relationship between four polymorphisms in the matrix metalloproteinases (MMP) gene and breast cancer risk: a meta-analysis.
[PMID 21455563] Analysis of matrix metalloproteinase-9 gene polymorphism -1562 C/T in patients suffering from systemic sclerosis with and without ulcers.
[PMID 21844877] Matrix metalloproteinase-9 genetic variations affect MMP-9 levels in obese children.
[PMID 22304569] Functional polymorphism located in mmp-9 gene promoter is strongly associated with obesity.
[PMID 23257253] Expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in recurrent chronic rhinosinusitis with nasal polyposis
[PMID 23734748] Association of genes of protease-antiprotease balance pathway to lung function and emphysema subtypes
[PMID 23813847] The association of genetic variants of matrix metalloproteinases with abdominal aortic aneurysm: a systematic review and meta-analysis
[PMID 23819814] Association of Genetic Polymorphisms in Matrix Metalloproteinase-9 and Coronary Artery Disease in Chinese Han Population: A Case-Control Study
[PMID 23819551] Genetic polymorphisms in matrix metalloproteinases (MMPs) and tissue inhibitors of MPs (TIMPs), and bladder cancer susceptibility
[PMID 24043671] A Functional Single Nucleotide Polymorphism -1562C>T in the Matrix Metalloproteinase-9 Promoter Is Associated With Type 2 Diabetes and Diabetic Foot Ulcers
[PMID 24291031] Association of APOE, GCPII and MMP9 polymorphisms with common diseases and lipid levels in an older adult/elderly cohort
[PMID 24357512] Gelatinase B (-1562C/T) polymorphism in tumor progression and invasion of breast cancer
[PMID 23010359] Functional matrix metalloproteinase (MMP)-9 genetic variants modify the effects of hemodialysis on circulating MMP-9 levels.
[PMID 23274712] Genetic polymorphisms and the risk of myocardial infarction in patients under 45 years of age.
[PMID 25738347] MMP-9 -1562 C>T () Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions
[PMID 26013370] Matrix Metalloproteinase-9 Polymorphism 1562 C > T () Associated with Protection Against Placental Malaria
[PMID 26754027] Genetic polymorphisms in MMP 2, 3 and 9 genes and the susceptibility of osteosarcoma in a Chinese Han population. More Information
This SNP increases gene production of MMP-9 and was associated with severity of heart hardening of the arteries.
- One T allele=1.14X increased risk for heart attack (p=0.06) [R]
- TT=1.33X increased risk for heart attack (p=0.19)[R]
- One T= 9.1X increased breast cancer risk for whites and 3.6X increased breast cancer risk for mixed ethnicities [R]
- T=increased blood pressure and aortic stiffness in a high blood pressure population (R).
- T allele= increased plaque instability through increased degradation of the cellular structural support web (ECM).
- Has been associated with heart failure (HF) and overall risk of dying (R).
Population Alleles Frequency
| ethhicity | frequency |
|---|---|
| African/African-American | 0.1292 |
| Latino/Admixed American | 0.0696 |
| Ashkenazi Jewish | 0.1655 |
| East Asian | 0.1428 |
| European | 0.16 |
| Other (population not assigned) | 0.1563 |
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