This SNP increases gene production of MMP-9 and was associated with severity of heart hardening of the arteries.

  • One T allele=1.14X increased risk for heart attack (p=0.06) [R]
  • TT=1.33X increased risk for heart attack (p=0.19)[R]
  • One T= 9.1X increased breast cancer risk for whites and 3.6X increased breast cancer risk for mixed ethnicities [R]
  • T=increased blood pressure and aortic stiffness in a high blood pressure population (R).
  • T allele= increased plaque instability through increased degradation of the cellular structural support web (ECM).
  • Has been associated with heart failure (HF) and overall risk of dying (R).

 

rs3918242

Parent Gene: MMP9

Importance: 4
Less common allele: T = 16%
More common allele: C = 84%
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