Mechanism:

The Minor "T"  allele is associated with:

  • Protective against antipsychotic-induced weight gain (study population includes patients with schizophrenia) [R].

  • Increased risk of major depressive disorder. This data was not replicated multiple times however (population study of men and women from the United Kingdom) [R].

  • Increased glucose and acute insulin response (population study of only young men) [R].

  • Increased risk of type 2 diabetes and other cardiovascular diseases [R].

  • Increased risk of impaired glucose tolerance [R].

The Major "C" allele is associated with:

  • Increased risk of antipsychotic-induced weight gain, especially with clozapine and olanzapine treatment (CC) (Study population includes patients with schizophrenia) [R].

  • Increased risk of gaining 7-10% or more of baseline body weight (clinically significant weight gain) (CC) [R].

  • Higher BMI (CC) [R].

  • Increased feeding behavior (CC) [R].

This SNP is associated with:

  • Serotonin 5-HT [R].

  • Antipsychotic-induced weight gain [R].

rs3813929

Parent Gene: HTR2C

Importance: 4
Less common allele: T = 14%
More common allele: C = 86%
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