The G (major) allele is associated with:

GG genotype is associated with a higher response to antipsychotic treatment (R). This variation changes the structure of the dopamine receptor and causes it to be different than the normal protein [R]

  • Associated with schizophrenia (R1,R2,R3,R4,R5);
  • CG genotype is associated with a higher risk of schizophrenia compared to the CC and GG genotype (R1,R2); CG (heterozygotes) were 1.4 times more likely to develop schizophrenia [R] [R]
  • GG genotype is associated with a higher response to antipsychotic treatment (R1,R2)

This variation has also been associated with an increased risk of patients to be less responsive to Risperidone treatment [R]

rs1801028

Parent Gene: DRD2

Importance: 3
Less common allele: C = 3%
More common allele: G = 97%
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