Mechanism:

  • The T (minor) allele= Lower levels of FADS1 protein [R].

  • The C (major) allele= Normal levels of FADS1 protein [R].

The T (minor) allele is associated with:

  • Lower levels of arachidonic acid (Omega-6 polyunsaturated fatty acid) and higher levels of polyunsaturated fatty acid precursors [R].

  • Possible increased risk of coronary artery disease and ischemic stroke [R]. This still needs to be reproduced in future studies.

  • TT= Decreased LDL cholesterol (bad cholesterol) [R].

  • T= Increased levels of triglycerides [R].

The C (major) allele is associated with:

  • Higher levels of arachidonic acid (Omega-6 polyunsaturated fatty acid) and lower levels of polyunsaturated fatty acid precursors [R].

  • Possible decreased risk of coronary artery disease and ischemic stroke [R]. This still needs to be reproduced in future studies.

  • C= Increased LDL cholesterol [R].

  • C= Decreased levels of triglycerides [R].

rs174546

Parent Gene: FADS1

Importance: 5
Less common allele: T = 30%
More common allele: C = 70%
My Genotype: Log In
Risk Allele: T, A, T, T, C, A, T, T, T, T, T, T, T, T, T

Disease/Trait: Low Density Lipoprotein Cholesterol Measurement

The T allele of rs174546 is reported to be associated with Low Density Lipoprotein Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with LDL cholesterol.

Disease/Trait: Low Density Lipoprotein Cholesterol Measurement

The A allele of rs174546 is reported to be associated with Low Density Lipoprotein Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with LDL cholesterol.

Disease/Trait: Low Density Lipoprotein Cholesterol Measurement

The T allele of rs174546 is reported to be associated with Low Density Lipoprotein Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with LDL cholesterol.

Disease/Trait: Triglyceride Measurement

The T allele of rs174546 is reported to be associated with Triglyceride Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Triglycerides.

Disease/Trait: Total Cholesterol Measurement

The C allele of rs174546 is reported to be associated with Total Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cholesterol, total.

Disease/Trait: High Density Lipoprotein Cholesterol Measurement

The A allele of rs174546 is reported to be associated with High Density Lipoprotein Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Metabolic syndrome (HDL).

Disease/Trait: Metabolic Syndrome

The A allele of rs174546 is reported to be associated with Metabolic Syndrome (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Metabolic syndrome (HDL).

Disease/Trait: High Density Lipoprotein Cholesterol Measurement

The T allele of rs174546 is reported to be associated with High Density Lipoprotein Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with HDL cholesterol.

Disease/Trait: Total Cholesterol Measurement

The T allele of rs174546 is reported to be associated with Total Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cholesterol, total.

Disease/Trait: Triglyceride Measurement

The T allele of rs174546 is reported to be associated with Triglyceride Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Triglycerides.

Disease/Trait: Blood Metabolite Measurement

The T allele of rs174546 is reported to be associated with Blood Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine diacyl C38:5).

Disease/Trait: Glycerophospholipid Measurement

The T allele of rs174546 is reported to be associated with Glycerophospholipid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine diacyl C38:5).

Disease/Trait: Blood Metabolite Measurement

The T allele of rs174546 is reported to be associated with Blood Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine diacyl C40:6).

Disease/Trait: Glycerophospholipid Measurement

The T allele of rs174546 is reported to be associated with Glycerophospholipid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine diacyl C40:6).

Disease/Trait: Trans Fatty Acid Measurement

The T allele of rs174546 is reported to be associated with Trans Fatty Acid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Trans fatty acid levels (Cis/trans-18:2, EA).

Disease/Trait: Cis/Trans-18:2 Fatty Acid Measurement

The T allele of rs174546 is reported to be associated with Cis/trans-18:2 Fatty Acid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Trans fatty acid levels (Cis/trans-18:2, EA).

Disease/Trait: Gamma-Linolenic Acid Measurement

The T allele of rs174546 is reported to be associated with Gamma-linolenic Acid Measurement . Your genotype was not identified for this SNP so we are unable to comment on your association with Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid).

Disease/Trait: Triglyceride Measurement

The T allele of rs174546 is reported to be associated with Triglyceride Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with C-reactive protein levels or triglyceride levels (pleiotropy).

Disease/Trait: C-Reactive Protein Measurement

The T allele of rs174546 is reported to be associated with C-reactive Protein Measurement . Your genotype was not identified for this SNP so we are unable to comment on your association with C-reactive protein levels or triglyceride levels (pleiotropy).

Disease/Trait: High Density Lipoprotein Cholesterol Measurement

The T allele of rs174546 is reported to be associated with High Density Lipoprotein Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with C-reactive protein levels or HDL-cholesterol levels (pleiotropy).

Disease/Trait: C-Reactive Protein Measurement

The T allele of rs174546 is reported to be associated with C-reactive Protein Measurement . Your genotype was not identified for this SNP so we are unable to comment on your association with C-reactive protein levels or HDL-cholesterol levels (pleiotropy).