Mechanism:

  • The T (minor) allele= Increased DNA methylation of the FADS1 promoter, causing lower levels of FADS1 protein [R].

  • The G (major) allele= Normal levels of FADS1 protein [R].

The T (minor) allele is associated with:

  • Lower levels of arachidonic acid in the body [R]. Arachidonic acid is an Omega-6 polyunsaturated fatty acid.

  • Decreased risk of prostate cancer and better prognosis of disease progression due to lower arachidonic acid levels [R].

  • Decreased risk of developing Type II Diabetes [R].

  • Decreased risk of developing Coronary artery disease (CAD) [R].

  • Decreased LDL cholesterol (bad cholesterol) levels [R].

  • Possible increased need for fish oil supplements to maintain healthy omega-3 fatty acid levels [R].

  • Decreased risk of developing gingivitis, or gum disease [R].

The G (major) allele is associated with:

  • Increased levels of arachidonic acid in the body [R]. Arachidonic acid is an Omega-6 polyunsaturated fatty acid.

  • Increased risk of prostate cancer and worse prognosis of disease progression due to higher arachidonic acid levels [R].

  • Increased risk of developing Type II Diabetes [R].

  • Increased risk of developing Coronary artery disease (CAD) [R].

  • Increased LDL cholesterol (bad cholesterol) levels [R].

  • Possible decreased need for fish oil supplements to maintain healthy omega-3 fatty acid levels [R].

  • Increased risk of developing gingivitis, or gum disease [R].

rs174537

Parent Gene: MYRF

Importance: 5
Less common allele: T = 30%
More common allele: G = 70%
My Genotype: Log In
Risk Allele: G, A, T, T, T, G

Disease/Trait: Colorectal Cancer

The G allele of rs174537 is reported to be associated with Colorectal Cancer (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Colorectal cancer (East Asian).

Disease/Trait: Crohn's Disease

The A allele of rs174537 is reported to be associated with Crohn's Disease (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Crohn's disease (EA).

Disease/Trait: Blood Metabolite Measurement

The T allele of rs174537 is reported to be associated with Blood Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine diacyl C36:2).

Disease/Trait: Glycerophospholipid Measurement

The T allele of rs174537 is reported to be associated with Glycerophospholipid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine diacyl C36:2).

Disease/Trait: Trans Fatty Acid Measurement

The T allele of rs174537 is reported to be associated with Trans Fatty Acid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Trans fatty acid levels (Cis/trans-18:2, EA).

Disease/Trait: Cis/Trans-18:2 Fatty Acid Measurement

The T allele of rs174537 is reported to be associated with Cis/trans-18:2 Fatty Acid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Trans fatty acid levels (Cis/trans-18:2, EA).

Disease/Trait: Gamma-Linolenic Acid Measurement

The T allele of rs174537 is reported to be associated with Gamma-linolenic Acid Measurement . Your genotype was not identified for this SNP so we are unable to comment on your association with Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid).

Disease/Trait: Colorectal Cancer

The G allele of rs174537 is reported to be associated with Colorectal Cancer (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Colorectal cancer.