- Normal levels of brain derived neurotrophic factor (BDNF) within the body (AA)
- Normal levels of BDNF within the body (A)
- Decreased levels of BDNF within the body (T) [R].
- BDNF is essential in helping neurons survive in the body and encouraging the growth and development of new neurons. For these reasons, BDNF is very important in small developing children [R].
The T (minor) allele is associated with:
- Decreased cognitive processing speed in the brain [R].
- Attention Deficit Hyperactivity Disorder (ADHD) and worsening the symptoms of ADHD [R].
- Decreased development of neural pathways in infants [R].
- Behaviors similar to those found in subjects with Autism spectrum disorder (ASD) [R].
- Facilitated development of ASD in children [R].
- Increased social stress sensitivity [R]. This may lead to social anxiety.
- Increased positive response to electroconvulsive therapy (ECT) in patients being treated for major depressive disorder (MDD) [R].
- Increased weight gain during treatment with atypical antipsychotics in patients with schizophrenia [R].
- Development of more severe forms of asthma [R].
The A (major) allele is associated with:
- Increased cognitive processing speed in the brain [R].
- Decreased risk of ADHD [R].
- Decreased development of autism in infants and children [R].
- Decreased risk of social anxiety [R].
- Decreased response to ECT treatment in patients with MDD [R].
- Decreased weight gain during treatment with atypical antipsychotic drugs [R].
- Decreased development of severe asthma [R].
- Higher risk of developing bipolar disorder and schizophrenia (AT) [R]
- Higher risk of developing attention deficit hyperactive disorder [R] (n=202 Korean girls)
This SNP is associated with (unknown which alleles):