The Minor "A" allele is associated with:

  • Increased risk of lung cancer (AG and AA) (1.3x increase in AG, 1.8x increase in AA) [R]. Up to 14% of lung cancer incidence may be attributable to this allele [R, R2].

  • Increased addiction to smoking cigarettes in smokers [R].

  • Increased tobacco dependence (AG and AA) [R]

  • Decreased levels of prepulse inhibition PPI (AA) [R]

  • Increase risk of developing Schizophrenia (AA) [R]

  • AG has slight increase of risk of developing Schizophrenia

  • AA has increased risk for Chronic Obstructive Pulmonary Disease (COPD) [R]

  • Decreased alcohol sensitivity (AA), less likely to feel buzzed [R] This can result in higher alcohol consumption

  • AA may increase the risk of alcohol abuse [R].

  • Increased inability to quit smoking during pregnancy (AG and AA) [R].

The Major "G" allele is associated with:

  • Normal range of risk for lung cancer (GG) [R]

  • Normal range of risk for Schizophrenia (GG) [R]

  • Normal range of risk for Chronic Obstructive Pulmonary Disease (COPD) [R]

  • 12% reduced risk of peripheral arterial disease (PAD) (GG) [R].

rs1051730

Parent Gene: CHRNA3

Importance: 4
Less common allele: A = 17%
More common allele: G = 83%
My Genotype: Log In
Risk Allele: T, A, T, G, A, G, A, A, A

Disease/Trait: Nicotine Dependence

The T allele of rs1051730 is reported to be associated with Nicotine Dependence (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Nicotine dependence.

Disease/Trait: Lung Carcinoma

The A allele of rs1051730 is reported to be associated with Lung Carcinoma (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Lung cancer.

Disease/Trait: Lung Adenocarcinoma

The T allele of rs1051730 is reported to be associated with Lung Adenocarcinoma (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Lung adenocarcinoma.

Disease/Trait: Smoking Behavior

The G allele of rs1051730 is reported to be associated with Smoking Behavior (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Smoking behavior.

Disease/Trait: Smoking Behavior

The A allele of rs1051730 is reported to be associated with Smoking Behavior (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Smoking behavior.

Disease/Trait: Smoking Behavior

The G allele of rs1051730 is reported to be associated with Smoking Behavior (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Smoking behavior (CPD).

Disease/Trait: Forced Expiratory Volume

The A allele of rs1051730 is reported to be associated with Forced Expiratory Volume (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1.

Disease/Trait: Response To Bronchodilator

The A allele of rs1051730 is reported to be associated with Response To Bronchodilator (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1.

Disease/Trait: Fev/Fec Ratio

The A allele of rs1051730 is reported to be associated with Fev/fec Ratio (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio in COPD.

Disease/Trait: Chronic Obstructive Pulmonary Disease

The A allele of rs1051730 is reported to be associated with Chronic Obstructive Pulmonary Disease (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio in COPD.

Disease/Trait: Response To Bronchodilator

The A allele of rs1051730 is reported to be associated with Response To Bronchodilator (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio in COPD.

Disease/Trait: Forced Expiratory Volume

rs1051730 is associated with Forced Expiratory Volume (R) . It is reported to have a 0.07976 unit decrease on Pre bronchodilator FEV1. No specific risk allele was identified in the study.

Disease/Trait: Fev/Fec Ratio

rs1051730 is associated with Fev/fec Ratio (R) . It is reported to have a 0.01729 unit decrease on Pre bronchodilator FEV1/FVC ratio. No specific risk allele was identified in the study.

Disease/Trait: Fev/Fec Ratio

The A allele of rs1051730 is reported to be associated with Fev/fec Ratio (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio.

Disease/Trait: Response To Bronchodilator

The A allele of rs1051730 is reported to be associated with Response To Bronchodilator (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio.