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CHRNA5
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs16969968 | |||
| rs1038461611 | |||
| rs1393430909 | |||
| rs982494622 | |||
| rs10709956 | |||
| rs11637635 | |||
| rs1164955136 | |||
| rs17408276 | |||
| rs2456019 | |||
| rs369161239 | |||
| rs471889 | |||
| rs481134 | |||
| rs495090 | |||
| rs495956 | |||
| rs555018 | |||
| rs57945453 | |||
| rs588765 | |||
| rs601079 | |||
| rs61012457 | |||
| rs621849 |
Summary
The CHRNA5 gene codes for cholinergic receptor nicotinic alpha 5 subunit (CHRNA5). CHRNA5 and other proteins combine to form a type of nicotinic acetylcholine receptor [R].
Nicotinic acetylcholine receptors help transmit signals in the brain and activate skeletal muscles. As their name suggests, these receptors bind nicotine (an addictive chemical found in cigarettes) and acetylcholine (a chemical messenger of the nervous system) [R].
CHRNA5 polymorphisms have been linked to nicotine addiction [R].
Protein names
Found in These Blog Articles
GHR Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
More Information
The CHRNA5 gene produces a component of nicotinic receptors. Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of receptors that can mediate fast signal transmission at synapses (R), as well as increase the release of several neurotransmitters (R).
Nicotine activates these receptors. The most abundant receptor variation in the brain is the 4²2 subtype. Some 4²2 receptors also contain an 5 subunit (R). Inclusion of an 5 subunit in the nicotinic receptor significantly increases the rate of receptor desensitization and calcium permeability (R). Higher CHRNA5 gene production results in more 5 subunit production and therefore more nictoine dependence risk (R).
Lower CHRNA5 gene production results in lower 5 subunit production. Inclusion of an 5 subunit in the nicotinic receptor significantly increases the rate of receptor desensitization (R), which increases nicotine dependence risk.
Lifestyle & Supplement Interactions
Do not start smoking or nicotine.
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