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  3. TNFSF4

TNFSF4 (Tumor necrosis factor superfamily member 4)

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Summary of TNFSF4

This gene encodes a cytokine of the tumor necrosis factor family. It mediates adhesion of activated T cells to endothelial cells. Mutations of this gene are associated with lupus (R). 

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The Function of TNFSF4

Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

Protein names

Recommended name:

Tumor necrosis factor ligand superfamily member 4

Short name:

OX40L

Alternative name(s):

Glycoprotein Gp34
OX40 ligand
TAX transcriptionally-activated glycoprotein 1
CD antigen CD252

TNFSF4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10912564 (TNFSF4) ??
  2. RS1234313 (TNFSF4) ??
  3. RS1234314 (TNFSF4) ??
  4. RS2205960 (TNFSF4) ??
  5. RS3850641 (TNFSF4) ??
  6. RS3861950 (TNFSF4) ??

Top Gene-Substance Interactions

TNFSF4 Interacts with These Diseases

Disease Score

Substances That Increase TNFSF4

Substances Interaction Organism Category

Substances That Decrease TNFSF4

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: systemic sclerodermasystemic lupus erythematosusFrom NCBI Gene: Myocardial infarction 1From UniProt: Systemic lupus erythematosus (SLE): A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. [MIM:152700]

     From NCBI Gene: This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] From UniProt: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun
  • c-Fos

Gene Pathways:

  • Cytokine-cytokine receptor interaction

Induction:

By HTLV-1 transactivator p40-Tax.

Molecular Function:

  • Receptor Binding
  • Tumor Necrosis Factor Receptor Superfamily Binding

Biological Processes:

  • Acute Inflammatory Response
  • Cd4-Positive, Alpha-Beta T Cell Costimulation
  • Cellular Response To Lipopolysaccharide
  • Cellular Response To Nitrogen Dioxide
  • Cellular Response To Prostaglandin E Stimulus
  • Chemokine (C-C Motif) Ligand 11 Production
  • Cholesterol Metabolic Process
  • Defense Response To Nematode
  • Immune Response
  • Memory T Cell Activation
  • Negative Regulation Of Cytokine Secretion
  • Negative Regulation Of Interferon-Gamma Production
  • Negative Regulation Of Interleukin-17 Production
  • Negative Regulation Of Regulatory T Cell Differentiation
  • Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
  • Negative Regulation Of T-Helper 1 Cell Differentiation
  • Negative Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Activated T Cell Proliferation
  • Positive Regulation Of Alpha-Beta T Cell Proliferation
  • Positive Regulation Of B Cell Activation
  • Positive Regulation Of Cd4-Positive, Alpha-Beta T Cell Costimulation
  • Positive Regulation Of Cd4-Positive, Alpha-Beta T Cell Differentiation
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Immunoglobulin Mediated Immune Response
  • Positive Regulation Of Immunoglobulin Secretion
  • Positive Regulation Of Inflammatory Response
  • Positive Regulation Of Interferon-Gamma Production
  • Positive Regulation Of Interleukin-10 Production
  • Positive Regulation Of Interleukin-12 Production
  • Positive Regulation Of Interleukin-13 Production
  • Positive Regulation Of Interleukin-2 Production
  • Positive Regulation Of Interleukin-4-Dependent Isotype Switching To Ige Isotypes
  • Positive Regulation Of Interleukin-4 Production
  • Positive Regulation Of Interleukin-6 Production
  • Positive Regulation Of Memory T Cell Activation
  • Positive Regulation Of Memory T Cell Differentiation
  • Positive Regulation Of T Cell Cytokine Production
  • Positive Regulation Of T Cell Proliferation
  • Positive Regulation Of T-Helper 2 Cell Activation
  • Positive Regulation Of T-Helper 2 Cell Differentiation
  • Positive Regulation Of Type 2 Immune Response
  • Regulation Of Adaptive Immune Response
  • Regulation Of Inflammatory Response
  • Response To Nitrogen Dioxide
  • Response To Virus
  • Signal Transduction
  • T Cell Proliferation
  • T-Helper 2 Cell Activation
  • Tumor Necrosis Factor-Mediated Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| tumor necrosis factor (ligand) superfamily member 4| Ath1| Ath-1| atherosclerosis 1| CB1_001016004| CD134L| CD134 ligand| CD134(OX40)-ligand| CD252| EGK_01976| glycoprotein Gp34| GP34| OX40 antigen ligand| OX40L| OX-40L| OX40 ligand| OX40L protein| OX4OL| PAL_GLEAN10017789| PANDA_005151| tax-transcriptionally activated glycoprotein 1 (34kD)| tax-transcriptionally activated glycoprotein 1 ligand| TNFRSF4| TNLG2B| TREES_T100015819| tumor necrosis factor ligand 2B| tumor necrosis factor (ligand) superfamily, member 4| Tumor necrosis factor ligand superfamily member 4| tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa)| tumor necrosis factor receptor superfamily, member 4-like protein| TXGP1| Txgp1l| UY3_08379| tnfsf4

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