Summary of TNFSF4
This gene encodes a cytokine of the tumor necrosis factor family. It mediates adhesion of activated T cells to endothelial cells. Mutations of this gene are associated with lupus (R).
The Function of TNFSF4
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
Protein names
Recommended name:
Tumor necrosis factor ligand superfamily member 4Short name:
OX40LAlternative name(s):
Glycoprotein Gp34OX40 ligand
TAX transcriptionally-activated glycoprotein 1
CD antigen CD252
- RS10912564 (TNFSF4) ??
- RS1234313 (TNFSF4) ??
- RS1234314 (TNFSF4) ??
- RS2205960 (TNFSF4) ??
- RS3850641 (TNFSF4) ??
- RS3861950 (TNFSF4) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
TNFSF4 Interacts with These Diseases
| Disease | Score |
Substances That Increase TNFSF4
| Substances | Interaction | Organism | Category |
Substances That Decrease TNFSF4
| Substances | Interaction | Organism | Category |
Advanced Summary
Covered on Genetics Home Reference: systemic sclerodermasystemic lupus erythematosusFrom NCBI Gene: Myocardial infarction 1From UniProt: Systemic lupus erythematosus (SLE): A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. [MIM:152700]
From NCBI Gene: This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] From UniProt: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
By HTLV-1 transactivator p40-Tax.
Molecular Function:
Biological Processes:
- Defense Response To Nematode
- Acute Inflammatory Response
- Positive Regulation Of T Cell Cytokine Production
- Regulation Of Adaptive Immune Response
- Positive Regulation Of Type 2 Immune Response
- Positive Regulation Of Immunoglobulin Mediated Immune Response
- Immune Response
- Signal Transduction
- Cholesterol Metabolic Process
- Positive Regulation Of Cell Proliferation
- Response To Virus
- Negative Regulation Of Interferon-Gamma Production
- Negative Regulation Of Interleukin-17 Production
- Positive Regulation Of Interferon-Gamma Production
- Positive Regulation Of Interleukin-10 Production
- Positive Regulation Of Interleukin-12 Production
- Positive Regulation Of Interleukin-13 Production
- Positive Regulation Of Interleukin-2 Production
- Positive Regulation Of Interleukin-4 Production
- Positive Regulation Of Interleukin-6 Production
- Tumor Necrosis Factor-Mediated Signaling Pathway
- Memory T Cell Activation
- T-Helper 2 Cell Activation
- Response To Nitrogen Dioxide
- Cellular Response To Nitrogen Dioxide
- Cd4-Positive, Alpha-Beta T Cell Costimulation
- T Cell Proliferation
- Positive Regulation Of T Cell Proliferation
- Positive Regulation Of Activated T Cell Proliferation
- Positive Regulation Of Cd4-Positive, Alpha-Beta T Cell Differentiation
- Positive Regulation Of Memory T Cell Differentiation
- Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Negative Regulation Of Regulatory T Cell Differentiation
- Negative Regulation Of T-Helper 1 Cell Differentiation
- Positive Regulation Of T-Helper 2 Cell Differentiation
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Alpha-Beta T Cell Proliferation
- Negative Regulation Of Cytokine Secretion
- Regulation Of Inflammatory Response
- Positive Regulation Of Inflammatory Response
- Positive Regulation Of B Cell Activation
- Positive Regulation Of Immunoglobulin Secretion
- Cellular Response To Lipopolysaccharide
- Cellular Response To Prostaglandin E Stimulus
- Chemokine (C-C Motif) Ligand 11 Production
- Positive Regulation Of Cd4-Positive, Alpha-Beta T Cell Costimulation
- Positive Regulation Of Memory T Cell Activation
- Positive Regulation Of T-Helper 2 Cell Activation
- Positive Regulation Of Interleukin-4-Dependent Isotype Switching To Ige Isotypes