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  3. SLC4A4

SLC4A4 (Solute carrier family 4 member 4)

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The Function of SLC4A4

Isoform 2: May have a higher activity than isoform 1.

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Protein names

Recommended name:

Electrogenic sodium bicarbonate cotransporter 1

Short name:

-

Alternative name(s):

Sodium bicarbonate cotransporter
Na(+
Solute carrier family 4 member 4
kNBC1

SLC4A4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10022637 (SLC4A4) ??
  2. RS148635969 (SLC4A4) ??
  3. RS2363719 (SLC4A4) ??
  4. RS2579330 (SLC4A4) ??

Top Gene-Substance Interactions

SLC4A4 Interacts with These Diseases

Disease Score

Substances That Increase SLC4A4

Substances Interaction Organism Category

Substances That Decrease SLC4A4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • HNF-1A
  • HNF-1
  • E2F-1
  • E2F-4
  • E2F-5

Tissue specificity:

Isoform 1 is expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal chord. Corneal endothelium cells express only isoform 1 (at protein level). Isoform 2 is specifically expressed in kidney at the level of proximal tubules.

Gene Pathways:

  • Bile secretion
  • Pancreatic secretion
  • Proximal tubule bicarbonate reclamation
  • Transmembrane transport of small molecules

Enzyme Regulation:

Inhibited by stilbene derivatives and regulated by cyclic AMP.

Molecular Function:

  • Inorganic Anion Exchanger Activity
  • Sodium:Bicarbonate Symporter Activity

Biological Processes:

  • Bicarbonate Transport
  • Regulation Of Intracellular Ph
  • Sodium Ion Transport
  • Transport

Drug Bank:

  • Sodium Bicarbonate
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_10498| AS27_05647| AS28_11971| CB1_001109023| D623_10017404| Deoxycytidine kinase| duodenal sodium bicarbonate cotransport protein NBC1| EGK_15809| electrogenic sodium bicarbonate cotransporter 1| electrogenic sodium bicarbonate cotransporter 1-like protein| electrogenic sodium bicarbonate cotransporter NBCe1 variant D| GW7_08981| H920_15829| hhNMC| hnbc1| I79_021405| KNBC| kNBC1| MDA_GLEAN10010897| N300_02115| N301_14253| N303_14663| N305_13637| N306_13389| N307_08098| N308_12760| N310_06970| N311_02853| N320_01465| N321_13589| N322_13425| N324_12273| N325_11872| N327_12538| N329_04785| N330_13230| N332_01878| N335_04630| N336_00748| Na(+)/HCO3(-) cotransporter| Na+HCO3- cotransporter 4| Na+-HCO3- exchanger| NBC| NBC1| NBC2| Nbc4| NBCE1| NBCe1-A| NBC-like protein| PAL_GLEAN10004306| pancreas sodium bicarbonate cotransporter| PANDA_008201| parotid gland sodium bicarbonate cotransporter| PNBC| SLC4A5| sodium bicarbonate cotransporter| sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas)| sodium bicarbonate cotransporter member 4| solute carrier family 4 (anion exchanger), member 4| solute carrier family 4 (sodium bicarbonate cotransporter), member 4| solute carrier family 4, sodium bicarbonate cotransporter, member 4| solute carrier family 4, sodium bicarbonate cotransporter, member 4, brain type| solute carrier family 4, sodium bicarbonate cotransporter, member 4 isoform 4-like protein| solute carrier family 4, sodium bicarbonate cotransporter, member 5| TREES_T100019244| UY3_12741| XNBC1| Y1Q_030471| Y956_01829| Z169_04845| slc4a4

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