The Function of SLC4A4
Isoform 2: May have a higher activity than isoform 1.
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Protein names
Recommended name:
Electrogenic sodium bicarbonate cotransporter 1Short name:
-Alternative name(s):
Sodium bicarbonate cotransporterNa(+
Solute carrier family 4 member 4
kNBC1
- RS10022637 (SLC4A4) ??
- RS148635969 (SLC4A4) ??
- RS2363719 (SLC4A4) ??
- RS2579330 (SLC4A4) ??
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Top Gene-Substance Interactions
SLC4A4 Interacts with These Diseases
Disease | Score |
Substances That Increase SLC4A4
Substances | Interaction | Organism | Category |
Substances That Decrease SLC4A4
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 1 is expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal chord. Corneal endothelium cells express only isoform 1 (at protein level). Isoform 2 is specifically expressed in kidney at the level of proximal tubules.
Gene Pathways:
Enzyme Regulation:
Inhibited by stilbene derivatives and regulated by cyclic AMP.