Summary of SLC12A2
The gene codes for a protein, solute carrier family 12 member 2. It regulates sodium and chloride transport and reabsorption. The protein is vital to maintain ionic balance and cell volume. It is phosphorylated in response to DNA damage [R].
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The Function of SLC12A2
Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
Protein names
Recommended name:
Solute carrier family 12 member 2Alternative name(s):
Basolateral Na-K-Cl symporterBumetanide-sensitive sodium-(potassium
- RS10089 (SLC12A2) ??
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Top Gene-Substance Interactions
SLC12A2 Interacts with These Diseases
| Disease | Score |
Substances That Increase SLC12A2
| Substances | Interaction | Organism | Category |
Substances That Decrease SLC12A2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in many tissues.
Enzyme Regulation:
Activated by WNK3.
Molecular Function:
- Sodium:Potassium:Chloride Symporter Activity
- Ammonium Transmembrane Transporter Activity
- Protein Kinase Binding
Biological Processes:
- Transport
- Ion Transport
- Potassium Ion Transport
- Sodium Ion Transport
- Hyperosmotic Response
- Gamma-Aminobutyric Acid Signaling Pathway
- Aging
- Ammonium Transport
- Transepithelial Chloride Transport
- Positive Regulation Of Cell Volume
- Transepithelial Ammonium Transport