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  3. SLC12A2

SLC12A2 (Solute carrier family 12 member 2)

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Summary of SLC12A2

The gene codes for a protein, solute carrier family 12 member 2. It regulates sodium and chloride transport and reabsorption. The protein is vital to maintain ionic balance and cell volume. It is phosphorylated in response to DNA damage [R].

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The Function of SLC12A2

Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.

Protein names

Recommended name:

Solute carrier family 12 member 2

Alternative name(s):

Basolateral Na-K-Cl symporter
Bumetanide-sensitive sodium-(potassium

SLC12A2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10089 (SLC12A2) ??

Top Gene-Substance Interactions

SLC12A2 Interacts with These Diseases

Disease Score

Substances That Increase SLC12A2

Substances Interaction Organism Category

Substances That Decrease SLC12A2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • C/EBPbeta
  • STAT5A

Tissue specificity:

Expressed in many tissues.

Gene Pathways:

  • Pancreatic secretion
  • Transmembrane transport of small molecules
  • Salivary secretion

Enzyme Regulation:

Activated by WNK3.

Molecular Function:

  • Ammonium Transmembrane Transporter Activity
  • Protein Kinase Binding
  • Sodium:Potassium:Chloride Symporter Activity

Biological Processes:

  • Aging
  • Ammonium Transport
  • Gamma-Aminobutyric Acid Signaling Pathway
  • Hyperosmotic Response
  • Ion Transport
  • Positive Regulation Of Cell Volume
  • Potassium Ion Transport
  • Sodium Ion Transport
  • Transepithelial Ammonium Transport
  • Transepithelial Chloride Transport
  • Transport

Drug Bank:

  • Quinethazone
  • Bumetanide
  • Potassium Chloride
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Na-K-Cl cotransporter| solute carrier family 12 (sodium/potassium/chloride transporter)| A306_15633| AS28_00840| basolateral NaK(2Cl) cotransporter| basolateral Na-K-Cl symporter| BSC| bsc2| bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1| CB1_001532019| D623_10026951| GW7_06510| H920_06595| I79_017861| little ears| lte| M91_19170| M959_02945| mBSC2| MDA_GLEAN10020654| N300_07637| N301_09383| N302_08932| N303_06541| N305_03242| N306_01911| N307_10008| N309_06163| N310_03066| N311_12613| N320_11471| N322_01079| N327_08054| N330_02901| N333_08954| N334_01323| N336_06069| N341_04222| Na-K-2Cl- cotransporter| Na-K-2Cl cotransporter 1| NKCC1| PAL_GLEAN10025111| PANDA_006054| PPP1R141| protein phosphatase 1, regulatory subunit 141| slc12a4| sodium/potassium/chloride cotransporters| sodium/potassium/chloride transporters| Solute carrier family 12 member 1| solute carrier family 12, member 2| solute carrier family 12 (potassium/chloride transporters), member 2| solute carrier family 12 (potassium/chloride transporters), member 4| solute carrier family 12 (sodium/potassium/chloride transporter), member 2| solute carrier family 12 (sodium/potassium/chloride transporters), member 2| sy-ns| TREES_T100005572| UY3_04188| Y1Q_027426| Z169_14906| zfnkcc1| zmp:0000000537| slc12a2

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