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RUNX1
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs1268404906 | |||
| rs1487186804 | |||
| rs192963187 | |||
| rs114825715 | |||
| rs115531476 | |||
| rs115559227 | |||
| rs1395545094 | |||
| rs141344594 | |||
| rs146276307 | |||
| rs182118938 | |||
| rs375142384 | |||
| rs377213940 | |||
| rs558793739 | |||
| rs78816512 | |||
| rs932923205 | |||
| rs1014633812 | |||
| rs111527738 | |||
| rs112484410 | |||
| rs150042294 | |||
| rs200430800 |
Find on This Page
Summary
RUNX1 codes for a protein that suppresses the cell proliferation inhibitor p21. It helps regulate the development of immune cells. Variants of RUNX1 may play a role in male-pattern baldness and rheumatoid arthritis by disregulating RUNX1, thereby increasing p21 activity. Chromosomal translocations are also linked to several types of leukemia [R].
Lifestyle, diet, and supplement modifications may counteract the effects of these variants by decreasing p21 production and modulating pro- and anti-inflammatory immune cells or proteins.
Protein names
Found in These Blog Articles
GHR Function
The RUNX1 gene provides instructions for making a protein called runt-related transcription factor 1 (RUNX1). Like other transcription factors, the RUNX1 protein attaches (binds) to specific regions of DNA and helps control the activity of particular genes. This protein interacts with another protein called core binding factor beta or CBFβ (produced from the CBFB gene), which helps RUNX1 bind to DNA and prevents it from being broken down. Together, these proteins form one version of a complex known as core binding factor (CBF). The RUNX1 protein turns on (activates) genes that help control the development of blood cells (hematopoiesis). In particular, it plays an important role in development of hematopoietic stem cells, early blood cells that have the potential to develop into all types of mature blood cells such as white blood cells, red blood cells, and platelets.
More Information
The RUNX1 gene codes for RUNX family transcription factor 1 (RUNX1), a protein that alters the activity of genes. It also regulates the production of proteins involved in T cell development and activation, including RAS guanyl-releasing protein 1 [R, R, R, R, R].
More specifically, RAS guanyl-releasing protein 1 may be necessary for promoting the survival of T cells that are unresponsive to the body’s own tissues [R, R, R].
The survival of these T cells is crucial for preventing autoimmunity, or immune reactions that target parts of the body. In the autoimmune disorder rheumatoid arthritis, aberrant immune reactions target the body’s joints [R].
Although this protein may play a role in preventing autoimmunity, RUNX1 may also be involved in the development of pro-inflammatory T helper type 1 (Th1) cells. Multiple studies have provided evidence that a Th1-dominant immune response may underlie rheumatoid arthritis progression [R, R, R].
Variants of RUNX1 have been associated with rheumatoid arthritis. These variants may dysregulate the production of RUNX1, which may result in the development of T cells that are reactive to joints, as well as the development of pro-inflammatory Th1 cells [R, R, R, R, R].
Studies have shown that RUNX1 may suppress p21, a protein that blocks cell proliferation by regulating cell division [R].
Deletion of RUNX1 has been reported to perturb hair growth cycles and hair structure, suggesting that RUNX1 promotes hair follicle cell growth and expansion (proliferation) [R, R].
Variants of RUNX1 have been associated with male-pattern baldness. These variants may lower the production or activity of RUNX1, resulting in increased p21 activity, reduced cell proliferation, and hair loss [R, R, R, R, R].
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