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  2. Genes
  3. PRL

PRL (Prolactin)

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The Function of PRL

Prolactin acts primarily on the mammary gland by promoting lactation.

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Protein names

Recommended name:

Prolactin

Short name:

PRL

PRL SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1341239 (PRL) ??
  2. RS4236016 (PRL) ??

Top Gene-Substance Interactions

PRL Interacts with These Diseases

Disease Score

Substances That Increase PRL

Substances Interaction Organism Category

Substances That Decrease PRL

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • AP-1
  • c-Jun
  • C/EBPalpha
  • STAT5A
  • STAT5B
  • IRF-1
  • FOXO1a
  • FOXO1
  • GATA-2

Gene Pathways:

  • Disease
  • Immune System
  • Signal Transduction
  • Neuroactive ligand-receptor interaction
  • Cytokine-cytokine receptor interaction
  • Jak-STAT signaling pathway

Molecular Function:

  • Prolactin Receptor Binding
  • Dna Binding
  • Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Factor Binding

Biological Processes:

  • Cell Proliferation
  • Cell Surface Receptor Signaling Pathway
  • Cellular Protein Metabolic Process
  • Female Pregnancy
  • Jak-Stat Cascade Involved In Growth Hormone Signaling Pathway
  • Lactation
  • Positive Regulation Of Jak-Stat Cascade
  • Regulation Of Multicellular Organism Growth
  • Adrenal Gland Development
  • Anterior/Posterior Pattern Specification
  • Branching Involved In Ureteric Bud Morphogenesis
  • Embryonic Hemopoiesis
  • Embryonic Limb Morphogenesis
  • Embryonic Skeletal System Development
  • Negative Regulation Of Neuron Differentiation
  • Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
  • Proximal/Distal Pattern Formation
  • Regulation Of Ossification
  • Sex Differentiation
  • Somatic Stem Cell Population Maintenance
  • Spleen Development
  • Steroid Biosynthetic Process
  • Thymus Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_06469| AS28_04326| AV290867| CB1_000595068| D623_10026598| decidual prolactin| EGK_14513| EH28_06258| GHA1| growth hormone A1| GW7_10981| H920_04828| M91_07772| M959_13955| MDA_GLEAN10020429| N300_08052| N301_12269| N302_10663| N303_07726| N305_08689| N306_11361| N307_09768| N308_02924| N309_04896| N320_09935| N321_01576| N324_12191| N327_12702| N328_01511| N329_03884| N331_04330| N332_12695| N333_09548| N334_02357| N335_02502| N340_14367| N341_06001| PAL_GLEAN10016402| PANDA_015608| preprolactin| prl1| Prl1a1| PRLB| PRLSD1| Prol| prolactin 2| prolactin family 1, subfamily a, member 1| Prolactin precursor-like protein| prolactin type 2a| prolactin type 2b| prolactin type 2c| prolactin type 3| Proxless| RATPRLSD1| RNPROL| TREES_T100011689| Y1Q_000816| Z169_01943| prl

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