Summary of MTNR1A
The MTNR1A gene codes for melatonin receptor 1A (MT1). This receptor is activated by the hormone melatonin . Melatonin is best known to induce sleep [R, R].
MT1 may influence [R]:
- Sleep conditions
- Mood disorders
- Learning and memory
- Drug abuse
- Cancer
0 users want this gene increased,
0 users want it decreased
Protein names
Recommended name:
Melatonin receptor type 1AAlternative name(s):
Mel-1A-RMel1a receptor
- RS6553010 (MTNR1A) ??
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Top Gene-Substance Interactions
MTNR1A Interacts with These Diseases
| Disease | Score |
Substances That Increase MTNR1A
| Substances | Interaction | Organism | Category |
Substances That Decrease MTNR1A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.
Gene Pathways:
Molecular Function:
Biological Processes:
- Cell Surface Receptor Signaling Pathway
- G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
- Aging
- Mating Behavior
- Circadian Rhythm
- Positive Regulation Of Cgmp Biosynthetic Process
- Camera-Type Eye Development
- Negative Regulation Of Insulin Secretion
Drug Bank:
- Agomelatine
- Ramelteon
- Tasimelteon
- Melatonin