• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. MTNR1A

MTNR1A (Melatonin receptor 1A)

Loading...

Summary of MTNR1A

The gene codes for a protein, melatonin receptor 1A. It is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length [R].

0 users want this gene increased, 0 users want it decreased

The Function of MTNR1A

High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

Protein names

Recommended name:

Melatonin receptor type 1A

Alternative name(s):

Mel-1A-R
Mel1a receptor

MTNR1A SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS6553010 (MTNR1A) ??

Top Gene-Substance Interactions

MTNR1A Interacts with These Diseases

Disease Score

Substances That Increase MTNR1A

Substances Interaction Organism Category

Substances That Decrease MTNR1A

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • RORalpha2
  • C/EBPalpha
  • STAT5A
  • STAT5B
  • GATA-1
  • E47
  • TGIF
  • LCR-F1

Tissue specificity:

Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction

Molecular Function:

  • Hormone Binding
  • Melatonin Receptor Activity
  • Organic Cyclic Compound Binding

Biological Processes:

  • Cell Surface Receptor Signaling Pathway
  • Circadian Rhythm
  • G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
  • Mating Behavior
  • Positive Regulation Of Cgmp Biosynthetic Process
  • Camera-Type Eye Development
  • Aging
  • Negative Regulation Of Insulin Secretion

Drug Bank:

  • Agomelatine
  • Ramelteon
  • Tasimelteon
  • Melatonin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| G-protein coupled receptor| Uncharacterized protein| MR| AS27_13312| AS28_03499| CB1_000362019| CKA| D623_10012190| EH28_09442| H920_03469| M91_02957| M959_12682| MDA_GLEAN10004202| mel1a| Mel-1a melatonin receptor| Mel1a melatonin receptor| Mel-1A-R| Mel1a receptor| melatonin receptor 1 A protein| melatonin receptor Mel1a| melatonin receptor protein 1A| melatonin receptor subtype A| melatonin receptor type 1A| melatonin receptor type 1A-A| melatonin receptor type 1A-like protein| melatonin receptor type 1a variant 1| melatonin receptor type 1a variant 2| MelR| mt1| N300_04165| N301_12020| N302_04141| N305_05822| N306_04683| N307_06778| N311_11045| N312_01235| N320_01595| N321_01195| N322_06744| N324_10980| N325_05125| N327_08982| N328_02160| N330_13270| N331_01881| N332_09597| N333_00828| N334_07238| N335_07843| N336_04984| N339_12574| N340_05525| N341_08555| PAL_GLEAN10021676| PANDA_012581| TREES_T100012409| Y1Q_017075| Y956_01150| Z169_11222| mtnr1a

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved