Summary of MTNR1A
The Function of MTNR1A
High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Protein names
Recommended name:
Melatonin receptor type 1AAlternative name(s):
Mel-1A-RMel1a receptor
- RS6553010 (MTNR1A) ??
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Top Gene-Substance Interactions
MTNR1A Interacts with These Diseases
| Disease | Score |
Substances That Increase MTNR1A
| Substances | Interaction | Organism | Category |
Substances That Decrease MTNR1A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.
Gene Pathways:
Molecular Function:
Biological Processes:
- Cell Surface Receptor Signaling Pathway
- Circadian Rhythm
- G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
- Mating Behavior
- Positive Regulation Of Cgmp Biosynthetic Process
- Camera-Type Eye Development
- Aging
- Negative Regulation Of Insulin Secretion
Drug Bank:
- Agomelatine
- Ramelteon
- Tasimelteon
- Melatonin