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LSP1
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs686722 | |||
| rs621679 | |||
| rs767035902 | |||
| rs11041476 | |||
| rs2089910 | |||
| rs7929248 | |||
| rs907612 | |||
| rs7938342 | |||
| rs11041487 | |||
| rs55840650 | |||
| rs56014530 | |||
| rs61868760 | |||
| rs61868761 | |||
| rs73410935 | |||
| rs7929314 | |||
| rs7943060 | |||
| rs907613 | |||
| rs1006379199 | |||
| rs138303369 | |||
| rs145078787 |
Find on This Page
Summary
The gene codes for a protein, lymphocyte-specific protein 1. It regulates neutrophil motility, adhesion to fibrinogen matrix proteins and transendothelial migration [R].
Variants of LSP1 may play a role in high blood pressure by increasing white blood cell counts and inflammation. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by reducing WBC activity.
Protein names
Found in These Blog Articles
GHR Function
May play a role in mediating neutrophil activation and chemotaxis.
More Information
The LSP1 gene encodes lymphocyte specific protein 1. This protein is mainly expressed in white blood cells (WBCs) and in the lining of blood vessels. It is believed to help WBCs stick to the surface of other tissues and move around in the body to where they are needed [R, R].
LSP1 is especially important for white blood cells to move through the lining of blood vessels, out of the blood and into inflamed or damaged tissues [R].
White blood cell (WBC) count is believed to be linked to high blood pressure. In fact, even among people within the normal range of blood pressure, those with higher WBC count tend to have higher blood pressure. Furthermore, high numbers of circulating WBCs may increase susceptibility to heart disease in people with high blood pressure [R, R, R].
At least one variant in the LSP1 gene has been associated with high blood pressure. Researchers currently aren’t sure exactly why this association exists; it is possible that LSP1’s effect on the movement of WBCs explains the link. Higher WBC count also increases inflammation, which in turn can increase blood pressure [R, R, R, R].
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