• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. KEAP1

KEAP1 (Kelch like ECH associated protein 1)

Loading...

Summary of KEAP1

The gene codes for a protein, kelch like ECH associated protein 1. An interaction causes expression of a catalytic subunit [R].

0 users want this gene increased, 0 users want it decreased

The Function of KEAP1

Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

Protein names

Recommended name:

Kelch-like ECH-associated protein 1

Alternative name(s):

Cytosolic inhibitor of Nrf2
INrf2
Kelch-like protein 19

KEAP1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11085735 (KEAP1) ??
  2. RS62131887 (KEAP1) ??

Top Gene-Substance Interactions

KEAP1 Interacts with These Diseases

Disease Score

Substances That Increase KEAP1

Substances Interaction Organism Category

Substances That Decrease KEAP1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • AhR
  • Arnt
  • c-Jun
  • NRF-2
  • c-Myb

Tissue specificity:

Broadly expressed, with highest levels in skeletal muscle.

Gene Pathways:

  • Immune System
  • Ubiquitin mediated proteolysis

Enzyme Regulation:

Ubiquitination and subsequent degradation of PGAM5 is inhibited by oxidative stress and sulforaphane. Sulforaphane also inhibits ubiquitination of NFE2L2/NRF2.

Molecular Function:

  • Transcription Factor Binding

Biological Processes:

  • Cellular Response To Interleukin-4
  • Cytoplasmic Sequestering Of Transcription Factor
  • In Utero Embryonic Development
  • Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
  • Positive Regulation Of Proteasomal Ubiquitin-Dependent Protein Catabolic Process
  • Proteasomal Ubiquitin-Independent Protein Catabolic Process
  • Protein Ubiquitination
  • Protein Ubiquitination Involved In Ubiquitin-Dependent Protein Catabolic Process
  • Regulation Of Epidermal Cell Differentiation
  • Transcription, Dna-Templated
  • Cellular Response To Organic Cyclic Compound
  • Flavonoid Metabolic Process
  • Malate Metabolic Process
  • Negative Regulation Of Gene Expression
  • Protein Oligomerization
  • Response To Immobilization Stress
  • Response To Metal Ion
  • Response To Thyroid Hormone
  • Selenium Compound Metabolic Process

Drug Bank:

  • Dimethyl Fumarate
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_02034| CB1_000418004| CG3962 gene product from transcript CG3962-RC| CG3962-PA| CG3962-PB| CG3962-PC| cytosolic inhibitor of Nrf2| dkeap-1| dKEAP1| Dmel_CG3962| EGK_10100| GW7_13272| INrf2| Keap1-PA| Keap1-PB| Keap1-PC| Kelch-like ECH-associated protein 1| kelch-like family member 19| kelch-like protein 19| KLHL19| M91_15268| MDA_GLEAN10009323| N303_05941| Nrf-2| NRF2 cytosolic inhibitor| PAL_GLEAN10002421| PANDA_010314| ring canal protein| TREES_T100002058| Y1Q_001597| keap1

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved