Summary of KEAP1
The gene codes for a protein, kelch like ECH associated protein 1. An interaction causes expression of a catalytic subunit [R].
The Function of KEAP1
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Protein names
Recommended name:
Kelch-like ECH-associated protein 1Alternative name(s):
Cytosolic inhibitor of Nrf2INrf2
Kelch-like protein 19
- RS11085735 (KEAP1) ??
- RS62131887 (KEAP1) ??
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Top Gene-Substance Interactions
KEAP1 Interacts with These Diseases
| Disease | Score |
Substances That Increase KEAP1
| Substances | Interaction | Organism | Category |
Substances That Decrease KEAP1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Broadly expressed, with highest levels in skeletal muscle.
Gene Pathways:
Enzyme Regulation:
Ubiquitination and subsequent degradation of PGAM5 is inhibited by oxidative stress and sulforaphane. Sulforaphane also inhibits ubiquitination of NFE2L2/NRF2.
Molecular Function:
Biological Processes:
- Cellular Response To Interleukin-4
- Cytoplasmic Sequestering Of Transcription Factor
- In Utero Embryonic Development
- Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Positive Regulation Of Proteasomal Ubiquitin-Dependent Protein Catabolic Process
- Proteasomal Ubiquitin-Independent Protein Catabolic Process
- Protein Ubiquitination
- Protein Ubiquitination Involved In Ubiquitin-Dependent Protein Catabolic Process
- Regulation Of Epidermal Cell Differentiation
- Transcription, Dna-Templated
- Cellular Response To Organic Cyclic Compound
- Flavonoid Metabolic Process
- Malate Metabolic Process
- Negative Regulation Of Gene Expression
- Protein Oligomerization
- Response To Immobilization Stress
- Response To Metal Ion
- Response To Thyroid Hormone
- Selenium Compound Metabolic Process