The Function of ISYNA1
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.
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Protein names
Recommended name:
Inositol-3-phosphate synthase 1Alternative name(s):
IPS 1Myo-inositol 1-phosphate synthase
MI-1-P synthase
MIP synthase
hIPS
Myo-inositol 1-phosphate synthase A1
hINO1
Top Gene-Substance Interactions
ISYNA1 Interacts with These Diseases
| Disease | Score |
Substances That Increase ISYNA1
| Substances | Interaction | Organism | Category |
Substances That Decrease ISYNA1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in testis, ovary, heart, placenta and pancreas. Weakly expressed in blood leukocyte, thymus, skeletal muscle and colon.
Gene Pathways:
Induction:
By glucose and lovastain. Up-regulation is prevented by mevalonic acid, farnesol, and geranylgeraniol. Up-regulated by E2F1.
Enzyme Regulation:
Inhibited by mood-stabilizing drugs such as valproate (VPA) and lithium.
Molecular Function:
Biological Processes:
- Inositol Biosynthetic Process
- Phospholipid Biosynthetic Process
- Inositol Phosphate Metabolic Process