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  3. ISYNA1

ISYNA1 (Inositol-3-phosphate synthase 1)

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The Function of ISYNA1

Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.

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Protein names

Recommended name:

Inositol-3-phosphate synthase 1

Alternative name(s):

IPS 1
Myo-inositol 1-phosphate synthase
MI-1-P synthase
MIP synthase
hIPS
Myo-inositol 1-phosphate synthase A1
hINO1

Top Gene-Substance Interactions

ISYNA1 Interacts with These Diseases

Disease Score

Substances That Increase ISYNA1

Substances Interaction Organism Category

Substances That Decrease ISYNA1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AhR
  • Arnt
  • STAT3
  • E2F-1
  • YY1
  • E47
  • p300

Tissue specificity:

Highly expressed in testis, ovary, heart, placenta and pancreas. Weakly expressed in blood leukocyte, thymus, skeletal muscle and colon.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Inositol phosphate metabolism

Induction:

By glucose and lovastain. Up-regulation is prevented by mevalonic acid, farnesol, and geranylgeraniol. Up-regulated by E2F1.

Enzyme Regulation:

Inhibited by mood-stabilizing drugs such as valproate (VPA) and lithium.

Molecular Function:

  • Inositol-3-Phosphate Synthase Activity

Biological Processes:

  • Inositol Biosynthetic Process
  • Inositol Phosphate Metabolic Process
  • Phospholipid Biosynthetic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_04222| AS27_02361| CB1_000878028| GW7_16350| H920_16002| INO1| INOS| Inositol-3-phosphate synthase 1-A| Inositol-3-phosphate synthase 1-B| IPS| IPS 1| IPS-1| isyna1-a| isyna1-b| M91_18732| M959_10465| MI-1-P synthase| MIP synthase| myo-inositol-1-phosphate synthase| Myo-inositol 1-phosphate synthase| myo-inositol 1-phosphate synthase A1| N300_07794| N301_06016| N303_15339| N307_05765| N312_08079| N330_08846| N339_06771| PAL_GLEAN10006691| QtsA-18180| testis secretory sperm-binding protein Li 200a| TREES_T100014723| Y1Q_018040| Y956_15542| Z169_12919| isyna1

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