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  3. IL2RA

IL2RA (Interleukin 2 receptor subunit alpha)

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Summary of IL2RA

IL2RA (interleukin 2 receptor subunit alpha) codes for part of the IL2 receptor (R).

It is associated with higher risk for rheumatoid arthritis and type one diabetes (R, R). 

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The Function of IL2RA

Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

Protein names

Recommended name:

Interleukin-2 receptor subunit alpha

Alternative name(s):

IL-2 receptor subunit alpha
IL-2-RA
IL-2R subunit alpha
IL2-RA
TAC antigen
p55
CD antigen CD25

IL2RA SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10795791 (IL2RA) ??
  2. RS10905716 (IL2RA) ??
  3. RS12251307 (IL2RA) ??
  4. RS12722486 (IL2RA) ??
  5. RS12722489 (IL2RA) ??
  6. RS12722495 (IL2RA) ??
  7. RS12722515 (IL2RA) ??
  8. RS12722556 (IL2RA) ??
  9. RS12722605 (IL2RA) ??
  10. RS2025345 (IL2RA) ??
  11. RS2104286 (IL2RA) ??
  12. RS3118470 (IL2RA) ??
  13. RS41295115 (IL2RA) ??
  14. RS61839660 (IL2RA) ??
  15. RS6602364 (IL2RA) ??
  16. RS706778 (IL2RA) ??
  17. RS706779 (IL2RA) ??
  18. RS7090512 (IL2RA) ??
  19. RS7911500 (IL2RA) ??
  20. RS791590 (IL2RA) ??
  21. RS8177757 (IL2RA) ??
  22. RS947474 (IL2RA) ??

Top Gene-Substance Interactions

IL2RA Interacts with These Diseases

Disease Score

Substances That Increase IL2RA

Substances Interaction Organism Category

Substances That Decrease IL2RA

Substances Interaction Organism Category

Advanced Summary

IL2RA (interleukin 2 receptor subunit alpha) codes for part of the IL2 receptor (R).

It is associated with higher risk for rheumatoid arthritis and type one diabetes (R, R). 

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • c-Jun
  • NF-kappaB1
  • STAT5B
  • TBP
  • STAT4
  • TFIID
  • c-Myb
  • NF-AT4

Gene Pathways:

  • Immune System
  • Cytokine-cytokine receptor interaction
  • Jak-STAT signaling pathway
  • Measles
  • Hematopoietic cell lineage

Molecular Function:

  • Drug Binding
  • Interleukin-2 Binding
  • Interleukin-2 Receptor Activity
  • Ras Guanyl-Nucleotide Exchange Factor Activity

Biological Processes:

  • Activation-Induced Cell Death Of T Cells
  • Apoptotic Process
  • Cell Proliferation
  • Cell Surface Receptor Signaling Pathway
  • Immune Response
  • Inflammatory Response
  • Inflammatory Response To Antigenic Stimulus
  • Mapk Cascade
  • Negative Regulation Of Defense Response To Virus
  • Negative Regulation Of Immune Response
  • Negative Regulation Of Inflammatory Response
  • Negative Regulation Of T Cell Proliferation
  • Notch Signaling Pathway
  • Positive Regulation Of Activated T Cell Proliferation
  • Positive Regulation Of T Cell Differentiation
  • Regulation Of T Cell Homeostatic Proliferation
  • Regulation Of T Cell Tolerance Induction

Drug Bank:

  • Basiliximab
  • Daclizumab
  • Aldesleukin
  • Denileukin Diftitox
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| p55| cytokine receptor| CD25| CD25 antigen| D623_10019418| H920_04097| IDDM10| IL-2 alpha receptor| IL2R| IL-2RA| IL-2-RA| IL2-RA| IL2RAC| IL-2R alpha| IL-2R alpha chain| IL2 receptor alpha| IL-2 Receptor alpha chain| IL-2 receptor alpha subunit| IL-2 receptor subunit alpha| IL-2R subunit alpha| IMD41| interleukin-15 receptor subunit alpha| interleukin-2 alpha receptor| interleukin 2 receptor alpha| interleukin 2 receptor, alpha| interleukin 2 receptor alpha chain| interleukin 2 receptor, alpha chain| interleukin-2 receptor alpha chain| Interleukin-2 receptor subunit alpha| Ly-43| M91_18189| MDA_GLEAN10014464| N311_03163| p55 chain| PANDA_009134| TAC antigen| TCGFR| UY3_03944| il2ra

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