Summary of IL2RA
The Function of IL2RA
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
Protein names
Recommended name:
Interleukin-2 receptor subunit alphaAlternative name(s):
IL-2 receptor subunit alphaIL-2-RA
IL-2R subunit alpha
IL2-RA
TAC antigen
p55
CD antigen CD25
- RS10905716 (IL2RA) ??
- RS12251307 (IL2RA) ??
- RS12722486 (IL2RA) ??
- RS12722489 (IL2RA) ??
- RS12722495 (IL2RA) ??
- RS12722515 (IL2RA) ??
- RS12722556 (IL2RA) ??
- RS12722605 (IL2RA) ??
- RS2025345 (IL2RA) ??
- RS2104286 (IL2RA) ??
- RS3118470 (IL2RA) ??
- RS41295115 (IL2RA) ??
- RS61839660 (IL2RA) ??
- RS6602364 (IL2RA) ??
- RS706778 (IL2RA) ??
- RS706779 (IL2RA) ??
- RS7090512 (IL2RA) ??
- RS7911500 (IL2RA) ??
- RS791590 (IL2RA) ??
- RS8177757 (IL2RA) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
IL2RA Interacts with These Diseases
| Disease | Score |
Substances That Increase IL2RA
| Substances | Interaction | Organism | Category |
Substances That Decrease IL2RA
| Substances | Interaction | Organism | Category |
Advanced Summary
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Drug Binding
- Interleukin-2 Binding
- Interleukin-2 Receptor Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
Biological Processes:
- Activation-Induced Cell Death Of T Cells
- Apoptotic Process
- Cell Proliferation
- Cell Surface Receptor Signaling Pathway
- Immune Response
- Inflammatory Response
- Inflammatory Response To Antigenic Stimulus
- Mapk Cascade
- Negative Regulation Of Defense Response To Virus
- Negative Regulation Of Immune Response
- Negative Regulation Of Inflammatory Response
- Negative Regulation Of T Cell Proliferation
- Notch Signaling Pathway
- Positive Regulation Of Activated T Cell Proliferation
- Positive Regulation Of T Cell Differentiation
- Regulation Of T Cell Homeostatic Proliferation
- Regulation Of T Cell Tolerance Induction
Drug Bank:
- Basiliximab
- Daclizumab
- Aldesleukin
- Denileukin Diftitox